The PDQ-Carer: development and validation of a summary index score.

Parkinsonism Relat Disord

University of Oxford, Department of Public Health, Old Road Campus, Headington, Oxford OX3 7LF, United Kingdom.

Published: April 2013

Introduction: The PDQ-Carer is a 29 item measure of health related quality of life for use with carers of people with Parkinson's disease. The original development of the instrument identified four domains. This study examined the possibility that the four domains could reasonably be summed to provide a single summary index score.

Methods: The PDQ-Carer was administered in a postal survey of patients and carers registered with local branches of Parkinson's UK. Data from the four domains of the PDQ-Carer was subjected to higher order factor analysis. Reliability and validity of the summary index were assessed.

Results: A total of 236 carer questionnaires were returned, a response rate of 61%. The mean age of the sample was 68.2 years (SD 9.49; range 25-89 years); 63.5% females, 21.3% males. Higher order principle components factor analysis produced one factor, accounting for 85.5% of the variance. The newly derived single index was found to be both internally reliable (alpha = 0.94) and valid through correlations with the eight domains of the SF-36 (all p < 0.001).

Discussion: The analyses undertaken here indicate that data from the PDQ-Carer can be presented in summary form. The index will provide an overall indication of the impact of caring. Furthermore, the single index reduces the number of statistical comparisons, and hence the role of chance, when exploring data from the PDQ-Carer.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.parkreldis.2012.11.018DOI Listing

Publication Analysis

Top Keywords

higher order
8
factor analysis
8
data pdq-carer
8
pdq-carer
6
pdq-carer development
4
development validation
4
summary
4
validation summary
4
summary score
4
score introduction
4

Similar Publications

The claustrum complex is viewed as fundamental for higher-order cognition; however, the circuit organization and function of its neuroanatomical subregions are not well understood. We demonstrated that some of the key roles of the CLA complex can be attributed to the connectivity and function of a small group of neurons in its ventral subregion, the endopiriform (EN). We identified a subpopulation of EN neurons by their projection to the ventral CA1 (EN.

View Article and Find Full Text PDF

Background: Women undergoing breast cancer surgery frequently experience postsurgical pain and fatigue, which reduces their quality of life. Although psychological factors have been shown to play a role in predicting postsurgical outcomes, the subacute recovery phase often remains underexplored. In this secondary analysis of data from a randomised controlled trial, we sought to investigate the predictive role of negative affect and experiential avoidance on postsurgical symptoms during both acute and subacute recovery.

View Article and Find Full Text PDF

Glow Discharge Optical Emission Coded Aperture Spectroscopy.

Anal Chem

January 2025

Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-41061, United States.

Glow discharge optical emission spectrometry (GDOES) allows fast and simultaneous multielemental analysis directly from solids and depth profiling down to the nanometer scale, which is critical for thin-film (TF) characterization. Nevertheless, operating conditions for the best limits of detection (LODs) are compromised in lieu of the best sputtering crater shapes for depth resolution. In addition, the fast transient signals from ultra-TFs do not permit the optimal sampling statistics of bulk analysis such that LODs are further compromised.

View Article and Find Full Text PDF

This study employs a clustering approach to assess the readiness for interprofessional education (IPE) among students enrolled in health-related study programs in Albania. Among a sample of 1470 students, complete data were available for 1383 participants, while 87 cases had missing data. Three distinct clusters were identified using hierarchical clustering analysis based on age and readiness domains: Teamwork (TW) and Professional Practice Identity (PPI).

View Article and Find Full Text PDF

Ganglioside-incorporating lipid nanoparticles as a polyethylene glycol-free mRNA delivery platform.

Biomater Sci

January 2025

Department of Bio and Brain Engineering, and KAIST Institute for Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.

Incorporation of polyethylene glycol (PEG) is widely used in lipid nanoparticle (LNP) formulation in order to achieve adequate stability due to its stealth properties. However, studies have detected the presence of anti-PEG neutralizing antibodies after PEGylated LNP treatment, which are associated with anaphylaxis, accelerated LNP clearance and premature release of cargo. Here, we report the development of LNPs incorporating ganglioside, a naturally occurring stealth lipid, as a PEG-free alternative.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!