AI Article Synopsis
- Surface-enhanced Raman scattering (SERS) is a sensitive spectroscopy technique that usually relies on specific metal substrates, but it has limitations in application.
- The new shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) technique utilizes silica-shell-coated gold nanoparticles to broaden the use of SERS to various surfaces and materials.
- The process of creating shell-isolated nanoparticles, with controlled sizes and shapes, takes about 3 hours, while the actual SHINERS measurement takes an additional 1-2 hours.
Article Abstract
Surface-enhanced Raman scattering (SERS) is a powerful fingerprint vibrational spectroscopy with a single-molecule detection limit, but its applications are generally restricted to 'free-electron-like' metal substrates such as Au, Ag and Cu nanostructures. We have invented a shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) technique, using Au-core silica-shell nanoparticles (Au@SiO(2) NPs), which makes SERS universally applicable to surfaces with any composition and any morphology. This protocol describes how to prepare shell-isolated nanoparticles (SHINs) with different well-controlled core sizes (55 and 120 nm), shapes (nanospheres, nanorods and nanocubes) and shell thicknesses (1-20 nm). It then describes how to apply SHINs to Pt and Au single-crystal surfaces with different facets in an electrochemical environment, on Si wafer surfaces adsorbed with hydrogen, on ZnO nanorods, and on living bacteria and fruit. With this method, SHINs can be prepared for use in ~3 h, and each subsequent procedure for SHINERS measurement requires 1-2 h.
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| http://dx.doi.org/10.1038/nprot.2012.141 | DOI Listing |
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