[Optimal extraction of puerarin from Pueraria lobata based on central composite design and response surface methodology].

Objective: To optimize the parameters of extraction technology for Puerarin from Pueraria lobata by Central Composite Design-Response Surface Methodology.

Methods: Used the ratio of dosage liquid and extraction time as the examination factor,the content of puerarin for the extraction percentage as the index. The multielement linear model and the polynomial model were used to describe the mathematics relation with response surface.

Results: The optimal extraction technology was as follows: ratio of herb-to-solvant was 1: 8.88 (W/V) and extraction time was 150 min. The coefficient correlation was 0.9977 and closed to the predicted value.

Conclusion: The results are accordant with model predictions. The technology can be used as the extraction process of puerarin from Pueraria lobata.