In 2005, the Scottish Executive recommended that young people with severe mental health difficulties should be managed in the community wherever possible. This study reports on the clinical outcomes associated with the development of a Child and Adolescent Mental Health (CAMH) Intensive Treatment Service (ITS) embedded within a Tier Four CAMHS structure. Following intervention, mean CGAS ratings significantly improved by 16 points (p<0.001) and HoNOSCA Clinical Scores significantly decreased by a mean of 6.94 points (p<0.001). This trend was replicated in self-report measures, where service users reported significant clinical improvements in mental health symptoms and indicators of quality of life. A CAMHS ITS, with close links to an adolescent inpatient unit, can provide a balanced care approach where young people with severe mental health difficulties can be treated in the community, where possible, without compromising on patient safety and quality of care.
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http://dx.doi.org/10.1177/1359104512468287 | DOI Listing |
EJHaem
February 2025
Service d'Hématologie Clinique et de Thérapie Cellulaire CHU de Bordeaux Pessac Nouvelle-Aquitaine France.
Introduction: Adults with relapsed or refractory Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukaemia (R/R Ph+ BCP-ALL) have a dismal outcome. Blinatumomab as a single agent has shown activity in R/R Ph- BCP-ALL, and second or third-generation tyrosine kinase inhibitors (TKIs) can produce high remission rates in Ph+ leukaemias. We aimed to assess the activity of blinatumomab and TKI in combination with intensive chemotherapy in the relapsed or refractory setting.
View Article and Find Full Text PDFOsteoarthr Cartil Open
March 2025
The Parker Institute, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Denmark.
Objective: Obesity is a major risk factor for osteoarthritis (OA). Adipose tissues may be linked to OA development through secretion of potential proinflammatory cytokines including neutrophil gelatinase-associated lipocalin (NGAL). Our objective was to assess changes in serum NGAL after a low-calorie diet (LCD) and subsequent glucagon-like peptide 1 receptor agonist (GLP-1 RA) treatment.
View Article and Find Full Text PDFIntroduction Acute poisoning in children is still a global health concern that necessitates visiting the emergency department that might associated with morbidity and mortality. It has an impact on social, economic, and health issues, particularly for children under five who account for the majority of poisonings worldwide. Poisoning can result in mild cases, serious complications, or even death; oral ingestion is the most common way that poisoning occurs in children.
View Article and Find Full Text PDFIDCases
January 2025
Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Sarawak, Malaysia.
We report a first case of ceftazidime-resistant pediatric melioidosis involving a previously healthy seven-year-old boy who presented with right lobar pneumonia complicated with a 5-cm lung abscess. Ceftazidime was initiated on Day-6 of admission when (ceftazidime-susceptible, minimum inhibitory concentration [MIC] 1.0 mcg/mL) was isolated from blood.
View Article and Find Full Text PDFIJID Reg
March 2025
IHU-Méditerranée Infection, Marseille, France.
Objectives: Analysis of current 2023-2024 (Mp) infection characteristics in adults.
Methods: A retrospective case series analysis was performed on polymerase chain reaction-positive adult patients admitted to the University Hospital of Marseille from April 2017 to June 2024. Clinical presentations, treatments, and outcomes were assessed.
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