Ruthenium-catalyzed pyrrole synthesis via oxidative annulation of enamides and alkynes.

Org Lett

State Key Laboratory of Element-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, PR China.

Published: January 2013

An efficient and regioselective ruthenium-catalyzed oxidative annulation of enamides with alkynes via the cleavage of C(sp(2))-H/N-H bonds is reported. The reactions can afford N-acetyl substituted or N-unsubstituted pyrroles by altering the reaction conditions slightly.

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Source
http://dx.doi.org/10.1021/ol303159hDOI Listing

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