Thrombosis in pregnancy: updates in diagnosis and management.

Hematology Am Soc Hematol Educ Program

Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.

Published: June 2013

AI Article Synopsis

  • Acute venous thromboembolism is a serious concern during pregnancy, especially in the weeks following delivery, requiring thorough diagnosis and immediate treatment.
  • Ultrasound venography is the preferred method for diagnosing deep venous thrombosis, while ventilation perfusion lung scans are favored for pulmonary thromboembolism due to lower radiation exposure.
  • Low-molecular-weight heparin is the recommended treatment for venous thromboembolism in pregnant patients, lasting at least 3 months and continuing for 6 weeks post-delivery, while newer anticoagulants like dabigatran, rivaroxaban, and apixaban are not advised for use during pregnancy.

Article Abstract

Acute venous thromboembolism poses significant problems in pregnancy, a time when objective diagnosis and prompt treatment are essential. Events can occur at any stage in pregnancy, but the period of greatest risk is in the weeks after delivery. Ultrasound venography remains the diagnostic technique of choice for deep venous thrombosis. For pulmonary thromboembolism, ventilation perfusion lung scan is usually preferred more than computerized tomography pulmonary angiography because of the lower maternal radiation dose and the lower prevalence of coexisting pulmonary problems. Low-molecular-weight heparin is the agent of choice for treatment of venous thromboembolism in pregnancy, and treatment should be provided for a minimum of 3 months and for at least 6 weeks after delivery. New anticoagulant agents such as dabigatran, rivaroxaban, or apixaban are not recommended for use in pregnancy.

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http://dx.doi.org/10.1182/asheducation-2012.1.203DOI Listing

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