AI Article Synopsis
- The study aimed to assess the effectiveness of carbetocin compared to oxytocin in preventing severe bleeding during cesarean deliveries of multiple pregnancies.
- It involved a retrospective comparison of two groups: those given carbetocin and those given oxytocin, focusing on the incidence of significant bleeding and related complications.
- Results showed no significant difference in severe postpartum hemorrhage rates between the two groups, indicating that carbetocin did not provide additional benefits over oxytocin in this context.
Article Abstract
Purpose: Cesarean deliveries of multiple pregnancies are associated with a high risk of hemorrhage. The aim of this study is to evaluate the efficacy of carbetocin administered systematically during cesarean deliveries of multiple pregnancies.
Methods: Single-center retrospective before-and-after study comparing the use of carbetocin to that of oxytocin during cesareans during two consecutive 6-month periods. A composite variable was predefined as the principal endpoint: any one or more of bleeding ≥1,500 mL, transfusion, hemoglobin reduction of 4 g/dL or more or operative intervention (surgery, embolization).
Results: In an intention-to-treat analysis, the comparison of the two groups (n = 24 before and n = 39 after) showed no difference for the occurrence of the composite variable (16.7 vs. 15.4 %, p = 0.89). Nor did the per-protocol analysis (n = 24 before and n = 27 after) differ for it (16.7 vs. 14.8 %, p = 0.86). Moreover, none of the secondary outcome measures studied-moderate blood loss, prescription of sulprostone, cell-saver use, and intravenous iron infusion-differed significantly between the two periods.
Conclusion: In our population of multiple pregnancies delivered by cesarean, carbetocin did not appear more effective than oxytocin in preventing severe postpartum hemorrhage.
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| http://dx.doi.org/10.1007/s00404-012-2646-2 | DOI Listing |
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