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Genes and proteins expression profile of 2D vs 3D cancer models: a comparative analysis for better tumor insights.
Cytotechnology
April 2025
University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali, 140413 India.
When juxtaposed with 2D cell culture models, multicellular tumor spheroids demonstrate a capacity to faithfully replicate certain features inherent to solid tumors. These include spatial architecture, physiological responses, the release of soluble mediators, patterns of gene expression, and mechanisms of drug resistance. The morphological and behavioural similarities between 3D-cultured cells and cells within tumor masses highlight the potential of these models in studying cancer biology and drug responses.
View Article and Find Full Text PDFComparing the efficacy of probiotic plus antibiotic with the Antibiotic Therapy alone on the recurrence of Bacterial Vaginosis.
Pak J Med Sci
January 2025
Asiya Fayyaz Department of Obstetrics and Gynecology, Nishtar Hospital, Multan, Pakistan.
Objective: To compare the efficacy of a probiotic plus antibiotic with antibiotic therapy alone for the prevention of the recurrence of bacterial vaginosis.
Method: A Randomized control trial was conducted in the Gynecological Department of Nishtar Hospital, Multan, between July 2022 and June 2023. One hundred and twenty (N=120) women with bacterial vaginosis, all cured with metronidazole, were enrolled and randomized.
Influence of age and gender on gait kinematics of pelvis and hip in healthy adults aged 19-60 years.
Front Bioeng Biotechnol
January 2025
MGM Centre of Human Movement Science, MGM School of Physiotherapy, MGM Institute of Health Sciences, Navi Mumbai, India.
Purpose: Pelvic and hip motion are pivotal in maintaining postural control and energy efficient gait. An insight into influence of age and gender on the coupled motion of hip and pelvis in gait-cycle will guide clinical rehabilitation strategies and pertinent technology-design for specific age-groups. Therefore, present study evaluated pelvic and hip-joint gait kinematics in healthy females and males across adult-hood.
View Article and Find Full Text PDFmodel of bacterial biofilm mineralization in complex humid environments: a proof of concept study.
Front Bioeng Biotechnol
January 2025
Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.
Background: Bacteria in physiological environments can generate mineralizing biofilms, which are associated with diseases like periodontitis or kidney stones. Modelling complex environments presents a challenge for the study of mineralization in biofilms. Here, we developed an experimental setup which could be applied to study the fundamental principles behind biofilm mineralization on rigid substrates, using a model organism and in a tailored bioreactor that mimics a humid environment.
View Article and Find Full Text PDFStudy of the impact on emissions and engine performance of diesel fuel additives made from cotton and castor blended seed oils.
Heliyon
January 2025
Department of Mechanical Engineering, Addis Ababa Science and Technology University, Addis Ababa, 16417, Ethiopia.
Many approaches have been implemented in order to reduce the emissions of particular pollutants without compromising engine performance. Cotton and castor mixed seed oil was chosen for the current study due to their distinct fatty acid composition and potential as a feedstock for bio-additives. Three fuel samples-99 % diesel and 1 % blended fuel (cottonseed oil + castor seed oil), 99.
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