In 2011, there was a large measles outbreak in Dublin. Nationally 285 cases were notified to the end of December 2011, and 250 (88%) were located in the Dublin region. After the first case was notified in week 6, numbers gradually increased, with 25 notified in June and a peak of 53 cases in August. Following public health intervention including a measles-mumps-rubella (MMR) vaccination campaign, no cases were reported in the Dublin region in December 2011. Most cases (82%) were children aged between 6 months and 14 years, and 46 cases (18%) were under 12 months-old. This is the first outbreak in Dublin to utilise a geographic information system for plotting measles cases on a digital map in real time. This approach, in combination with the analysis of case notifications, assisted the department of public health in demonstrating the extent of the outbreak. The digital mapping documented the evolution of two distinct clusters of 87 (35%) cases. These measles cases were infected with genotype D4-Manchester recently associated with large outbreaks across Europe. The two clusters occurred in socio-economically disadvantaged areas and were attributable to inadequate measles vaccination coverage due in part to the interruption of a school-based MMR2 vaccination programme.
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http://dx.doi.org/10.2807/ese.17.49.20330-en | DOI Listing |
Clin Infect Dis
January 2025
Provincial TB Services, BC Centre for Disease Control, Vancouver, BC.
Background: There is growing interest in using high-dose rifampin for tuberculosis treatment. Recent studies suggest that triple-dose rifampin (TDR; ≥30 mg/kg/day) may be unsafe. We updated a systematic review to investigate the safety and efficacy of TDR.
View Article and Find Full Text PDFJAMA Netw Open
December 2024
The Heller School for Social Policy and Management, Brandeis University, Waltham, Massachusetts.
Importance: Previous research suggests that a greater capacity of health care organizations to address patients' health-related social needs (HRSNs) is associated with lower physician burnout. However, individual physician-level engagement in addressing HRSNs has not been fully characterized, and its association with physician burnout remains understudied.
Objective: To characterize physicians' engagement in addressing HRSNs and examine its association with burnout.
Background: White matter hyperintensities (WMH) are very common brain MRI signal abnormalities linked to age, small vessel cerebrovascular disease, cognitive impairment, and dementia. Despite extensive research on WMH in Alzheimer's disease (AD), their prevalence in behavioral variant Frontotemporal dementia (bvFTD) remains less explored. Additionally, Latin American countries (LA) exhibit a higher prevalence of cerebrovascular disease due to distinct demographic, socioeconomic, cultural, and ethno-racial factors.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University Hospital Llandough, Llandough, United Kingdom.
Background: How and why healthcare utilisation and costs vary between patients with Alzheimer's disease dementia (ADD) is not well understood but is important in ensuring that efforts to improve the diagnosis and treatment of ADD are prioritised effectively. We aimed to investigate variation in healthcare resource utilisation (HCRU) among patients with ADD in England and identify the clinical and demographic factors which characterise subpopulations with the highest HCRU.
Method: This was a retrospective cohort study using Discover, a linked electronic health record database of 2.
Alzheimers Dement
December 2024
Global Brain Health Intitute, TCD, Dublin, Dublin, Ireland.
Background: A healing garden is a non-pharmacological approach that supports the interaction of humans and elements of nature towards improving well-being and quality of life. It has gained increased utilization in managing the health outcomes of older persons with and without dementia. However, there is a paucity of evidence of its use and benefits in African countries with increasing prevalence of dementia, such as Nigeria.
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