AI Article Synopsis
- The study examined how chlorpromazine behaves in the body after being infused intravenously in 25 children.
- Findings showed that the pharmacokinetic parameters for children are significantly different from those observed in adults.
- A strong correlation was found between age and two factors: how long the drug stays in the body (serum terminal half-life) and how quickly it's cleared (systemic clearance), indicating that children process chlorpromazine more quickly than adults.
Article Abstract
The pharmacokinetics of chlorpromazine after intravenous infusion were studied in 25 children. The pharmacokinetic parameters studied are markedly different from those reported for adults. A clear relationship was demonstrated between age, serum terminal half-life (r = 0.75) and systemic clearance (r = -0.43). It appears that the pharmacokinetics of chlorpromazine are more rapid in children than in adults.
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| http://dx.doi.org/10.2165/00003088-199018040-00005 | DOI Listing |
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