AI Article Synopsis
- Two new triterpenoid epimers, kadcoccitones A and B, along with a related compound called kadcoccitone C, were extracted from the plant Kadsura coccinea.
- The compounds have a unique structure, featuring a complex tetracyclic ring system and a side chain.
- Kadcoccitones A and C demonstrated anti-HIV-1 activity, with effective concentrations (EC50) of 47.91 and 32.66 μg/mL, indicating potential for further research in HIV treatment.
Article Abstract
A pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C(9) side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC(50) value of 47.91 and 32.66 μg/mL, respectively.
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Article Synopsis
- Two new triterpenoid epimers, kadcoccitones A and B, along with a related compound called kadcoccitone C, were extracted from the plant Kadsura coccinea.
- The compounds have a unique structure, featuring a complex tetracyclic ring system and a side chain.
- Kadcoccitones A and C demonstrated anti-HIV-1 activity, with effective concentrations (EC50) of 47.91 and 32.66 μg/mL, indicating potential for further research in HIV treatment.
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