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Novel Aspects of Immunogenetics and Post-Transplant Events in Kidney Transplantation.
Transpl Int
December 2024
Finnish Red Cross Blood Service, Helsinki, Finland.
HLA typing and matching have been crucial in kidney transplantation, but methods for assessing tissue histocompatibility have advanced significantly. While serological-level HLA typing remains common, it captures only a small fraction of true HLA variation, and molecular matching is already replacing traditional HLA matching. Recent studies have expanded our understanding of genetic tissue compatibility beyond HLA loci.
View Article and Find Full Text PDFApplication of exosomes for the regeneration of skin wounds: Principles, recent applications and limitations.
Tissue Cell
December 2024
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
In the medical field, wound healing poses significant challenges due to its complexity and time-consuming nature. Cell-free wound repair, notably the utilization of exosomes (EXOs), has made significant progress in recent years. Urine, saliva, umbilical cord, blood, mesenchymal stem cells and breast milk cells can be used to extract and purify EXOs, which are Nano-sized lipid bilayer vesicles.
View Article and Find Full Text PDFEndophilin A2 Deficiency Impairs Antibody Production in Humans.
J Clin Immunol
November 2024
Department of Human Genetics, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon.
Endophilin A2, the sole endophilin A family member expressed in hematopoietic cells, regulates various aspects of membrane dynamics, including autophagy and endocytosis. Recent studies in rodents highlight the essential role of endophilin A2 in modulating immune responses. Here we report a homozygous frameshift variant in the SH3GL1 gene (NM_003025.
View Article and Find Full Text PDFDisparities in Diagnosis, Access to Specialist Care and Treatment for Inborn Errors of Immunity.
J Allergy Clin Immunol Pract
October 2023
Program of Immunogenetics and Translational Immunology, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago, Chile; Hospital de niños Dr. Roberto del Rio, Santiago, Chile.
Inborn errors of immunity represent a rapidly expanding group of genetic disorders of the immune system. Significant advances have been made in recent years in diagnosis, including using genetic testing and newborn screening; treatment, including precision therapies, gene therapy and hematopoietic stem cell transplant; and development of patient registries to inform prevalence, understand morbidity of these disorders and guide the development of clinical trials. However, significant disparities due to age, race, ethnicity, socioeconomic status, or geographic location exist in all aspects of care of patients with inborn errors of immunity, beginning with delays in diagnosis and further compounded by impaired access to specialist care and treatment, leading to a notable impact on outcomes including morbidity and mortality.
View Article and Find Full Text PDFHow underappreciated autoinflammatory (innate immunity) mechanisms dominate disparate autoimmune disorders.
Front Immunol
October 2024
Department of Internal Medicine, Division of Rheumatology, Marmara University School of Medicine, Istanbul, Türkiye.
Article Synopsis
- The text talks about how our immune system can mistakenly attack our own body, which is called autoimmunity. It explains how scientists have learned about different types of immune responses over time.
- It introduces new ideas like "auto inflammation" to show a different way our immune system can act up against itself, beside the old ideas of autoimmunity.
- The text also mentions specific diseases, like rheumatoid arthritis and psoriasis, and explains how both parts of the immune system (innate and adaptive) work together in these conditions.
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