The aim of this study was to determine the effect of inspiratory loading on limb locomotor (LM) and respiratory muscle (RM) deoxygenation ([deoxy (Hb+Mb)]) using NIRS during constant-power cycling exercise. Sixteen, male cyclists completed three, 6-min trials. The intensity of the first 3-min of each trial was equivalent to ~80% V(O(2max)) (EX(80%)); during the final 3-min, subjects received an intervention consisting of either moderate inspiratory loading (Load(mod)), heavy inspiratory loading (Load(heavy)), or maximal exercise (Load(EX)). Load(heavy) significantly increased LM [deoxy(Hb+Mb)] from 12.2±9.0 μm during EX(80%) to 15.3±11.7 μm, and RM [deoxy(Hb+Mb)] from 5.9±3.6 μm to 9.5±6.6 μm. LM and RM [deoxy(Hb+Mb)] were significantly increased from EX(80%) to Load(EX); 12.8±9.1 μm to 16.4±10.3 μm and 5.9±2.9 μm to 11.0±6.4 μm, respectively. These data suggest an increase in respiratory muscle load increases muscle deoxy(Hb+Mb) and thus may indicate a reduction in oxygen delivery and/or increased oxygen extraction by the active muscles.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.resp.2012.11.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Engineered extracellular vesicles loaded in boronated cyclodextrin framework for pulmonary delivery.
Carbohydr Polym
March 2025
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China; Shenyang Pharmaceutical University, Shenyang 110016, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Extracellular vesicles (EVs) are promising therapeutic carriers for their ideal nano-size and intrinsic biocompatibility, while rapid clearance and limited targeting ability are the major setbacks of EVs. With minimal absorption into the systemic circulation, inhalation for pulmonary disease therapy minimizes off-target toxicity to other organs and offers a safe and effective treatment for respiratory disorders. Herein, a nano-grid carrier made of boronated cyclodextrin framework (BCF) was prepared for pH/HO responsive release of EVs.
View Article and Find Full Text PDFInspiratory effort and respiratory muscle activation during different breathing conditions in patients with weaning difficulties: An exploratory study.
Aust Crit Care
January 2025
KU Leuven, Department of Rehabilitation Sciences, Research Group for Rehabilitation in Internal Disorders, B-3000, Leuven, Belgium; University Hospitals Leuven, Department of Intensive Care Medicine, Leuven, Belgium.
Background: Recent studies suggest that fast and deep inspirations against either low or high external loads may provide patients with weaning difficulties with a training stimulus during inspiratory muscle training (IMT). However, the relationship between external IMT load, reflected by changes in airway pressure swings (ΔPaw), and total inspiratory effort, measured by oesophageal pressure swings (ΔPes), remains unexplored. Additionally, the association between ΔPes, ΔPaw, and inspiratory muscle activations remains unclear.
View Article and Find Full Text PDFThe impact of threshold-loaded inspiratory muscle training and respiratory biofeedback on preserving inspiratory muscle strength and vital capacity after CABG: a randomized clinical trial.
Am J Cardiovasc Dis
December 2024
Department of Cardiovascular Surgery, School of Medicine, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Objectives: Postoperative pulmonary complications (POPC) are common after cardiac surgeries such as coronary artery bypass grafting (CABG) and are influenced by factors including anesthesia and surgical trauma. Inspiratory muscle training (IMT) with visual biofeedback may mitigate these complications. This study investigates the impact of threshold loading inspiratory muscle training (TL-IMT) combined with respiratory biofeedback on the dynamic strength of inspiratory muscles (S-index) in patients undergoing CABG surgery during their hospitalization phase.
View Article and Find Full Text PDFHost-Directed Therapy with Inhalable Lovastatin Microspheres for Matrix Metalloproteinase Inhibition in Tuberculosis.
ACS Appl Bio Mater
January 2025
Institute of Nano Science and Technology (INST), Sector-81, Mohali, Punjab 140306, India.
Tuberculosis (TB) triggers a robust immune response, which leads to significant destruction of the lung tissue at the site of infection, aiding in the transmission of (Mtb) to the hosts. The excessive inflammatory response contributes heavily to extracellular matrix (ECM) damage, which is linked to high mortality rates among TB patients. Matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, are pivotal in the breakdown of the ECM, worsening tissue destruction.
View Article and Find Full Text PDFInhalable DNase I@Au hybrid nanoparticles for radiation sensitization and metastasis inhibition by elimination of neutrophil extracellular traps.
Biomaterials
January 2025
Department of Urology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China. Electronic address:
High-dose radiation therapy is a widely used clinical strategy to inhibit tumor growth. However, the rapid generation of excessive reactive oxygen species (ROS) triggers the formation of neutrophil extracellular traps (NETs), which capture free tumor cells in the bloodstream, promoting metastasis. In this study, we developed a hybrid nanoparticle composed of DNase I and gold (DNase I@Au) to enhance radiotherapy efficacy while mitigating metastasis by precisely eliminating NETs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!