Aim: To study the role of MTHFR gene polymorphism in patients with ischemic stroke (IS) in the Kyrgyz Republic.
Subjects And Methods: Molecular genetic testing of C677T polymorphism in the MTHFR gene was carried out in 107 Kyrgyz patients with prior IS. The patients were grouped according to the severity of motor impairments and the level of blood pressure (BP). The MTHFR C677T polymorphism was genotyped by polymerase chain reaction (PCR) using specific primers, followed by restriction of the resultant PCR products with the enzyme Hinf I.
Results: Severe motor impairments measured by the Scandinavian stroke scale was associated with the higher detection rate of the mutant TT genotypes of C677T polymorphism in the MTHFR gene (0.05 and 0.14; p < 0.04). As compared with stroke and normal BP, the development of stroke with high BP was associated with the presence of the mutant TT genotypes of C677T polymorphism in the MTHFR gene (1.9% versus 9.1%; p < 0.04).
Conclusion: The increased detection rate of the mutant TT genotypes of C677T polymorphism in the MTHFR gene is associated with severe motor impairments (p < 0.04) in patients with IS and with the development of stroke during high BP.
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