AI Article Synopsis
- The Wnt/ß-catenin signaling pathway is crucial for development and can lead to diseases when it's not properly regulated.
- Researchers discovered a new small molecule called WIKI4 that inhibits this signaling pathway and reduces the expression of ß-catenin target genes in cancer cell lines and human embryonic stem cells.
- WIKI4 works by targeting TNKS2, an enzyme that affects the stability of AXIN, which is important for regulating the pathway, and is structurally different from other known TNKS inhibitors.
Article Abstract
The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high throughput screening we have identified a new small molecule inhibitor of Wnt/ß-catenin signaling, WIKI4. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin signaling in cancer cell lines as well as in human embryonic stem cells. Furthermore, we demonstrate that WIKI4 mediates its effects on Wnt/ß-catenin signaling by inhibiting the enzymatic activity of TNKS2, a regulator of AXIN ubiquitylation and degradation. While TNKS has previously been shown to be the target of small molecule inhibitors of Wnt/ß-catenin signaling, WIKI4 is structurally distinct from previously identified TNKS inhibitors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515623 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050457 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!