AI Article Synopsis
- A 49-year-old woman with renal dialysis developed a primary pineal malignant melanoma, identified as a 35-mm tumor during a CT scan due to tinnitus and hearing issues.
- The tumor presented unique imaging characteristics and was surgically removed using an occipital transtentorial approach, with histology revealing malignant features such as pleomorphic cells and specific immunopositivity.
- Post-surgery management included whole-brain and local irradiation, resulting in no signs of recurrence or distant spread after 56 weeks, suggesting that radiotherapy alone may be an effective treatment for this rare tumor type.
Article Abstract
Background: Primary pineal malignant melanomas are uncommon intracranial tumor. Here we discuss and review a case of primary pineal malignant melanoma over its feature of imaging studies, pathological findings, and management.
Case Description: A 49-year-old woman receiving renal dialysis underwent computed tomography due to a 4-month history of tinnitus and hearing disturbance. A high-density 35-mm diameter tumor was detected in the pineal region; there was obstructive hydrocephalus. The tumor was heterogeneously hyperintense on T1-weighted magnetic resonance images, iso- and low-mixed intense on T2-weighted images with hemorrhagic components, and very low-intense on T2(*) images. A tumor was subtotally removed via the occipital transtentorial approach. Histologically, it consisted of densely proliferated spindle-shaped or polygonal cells with rich cytoplasmic melanin. The neoplastic cells manifested cellular pleomorphism, nuclear atypia, and mitosis (3/10 high-power fields) and were immunopositive for HMB45, Melan-A, and S100 protein. The MIB-1 index was 17.4%. Whole-body 18-fluoro-deoxyglucose positron emission tomography did not demonstrate any sites with hyper uptake. Examination of the skin and mucosa identified no lesions suggestive of melanoma. She underwent treatment with the whole brain and extended local boost irradiation. Chemotherapy was not delivered due to renal failure. Follow-up imaging studies showed no recurrence or distant lesions 56 weeks after surgery.
Conclusion: We report a rare case of primary pineal malignant melanoma with prolonged survival of more than 56 weeks after subtotal tumor resection followed by whole-brain and extended local irradiation without chemotherapy. Radiotherapy without chemotherapy might be sufficient for the treatment of this tumor.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512338 | PMC |
| http://dx.doi.org/10.4103/2152-7806.102348 | DOI Listing |
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