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Evidence for expression of 11β-hydroxysteroid dehydrogenase type3 (HSD11B3/HSD11B1L) in neonatal pig testis.
Mol Cell Biochem
September 2013
Department of Biochemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan.
11β-hydroxysteroid dehydrogenase (HSD11B) catalyzes the interconversion between active and inactive glucocorticoid, and is known to exist as two distinct isozymes: HSD11B1 and HSD11B2. A third HSD11B isozyme, HSD11B1L (SCDR10b), has recently been identified. Human HSD11B1L, which was characterized as a unidirectional NADP(+)-dependent cortisol dehydrogenase, appears to be specifically expressed in the brain.
View Article and Find Full Text PDF[Guidelines: reality and quality].
Urologe A
August 2012
Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Deutschland.
The aim of guidelines is to increase the quality of care in clinical practice. Any influence or financial support by the pharmaceutical industry must be excluded. In urology only two S3 guidelines have been published in German and all others are more or less recommendations (S1).
View Article and Find Full Text PDFThe unidirectional testicular tunneller: a simple, safe and novel device for orchidopexy in patients with palpable undescended testes.
Pediatr Surg Int
July 2012
Ministry of Defence Hospital Unit Derriford, Derriford Hospital, Plymouth, UK.
Purpose: Inguinal orchidopexy is already considered a safe procedure, this paper describes a simple new surgical instrument designed to make the operation easier, simpler and quicker, whilst reducing tissue trauma, in particular to the deep ring. The result of its use in two centres is presented.
Methods: A unidirectional testicular tunneller has been developed comprising a head, shaft and eye.
Differences in cadmium transport to the testis, epididymis, and brain in cadmium-sensitive and -resistant murine strains 129/J and A/J.
J Pharmacol Exp Ther
May 1999
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Although most animals with scrotal testes are susceptible to cadmium-induced testicular toxicity, strain-related differences are seen in mice. Resistant murine strains demonstrate a decreased cadmium concentration in the testis and also in the epididymis and seminal vesicle. In this study we analyzed cadmium transport into tissues with a vascular barrier, the testis, epididymis, and brain, in an attempt to characterize the mechanisms of strain resistance to cadmium-induced testicular toxicity.
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