Employing a click chemistry approach we have synthesized a novel triazole-linked cationic porphyrin-β-carboline conjugate which exhibited remarkable photocytotoxicity against the A549 cancer cell line (IC(50) = 60 nM).
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Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, China.
Photodynamic immunotherapy (PIT) has emerged as a promising approach for efficient eradication of primary tumors and inhibition of tumor metastasis. However, most of photosensitizers (PSs) for PIT exhibit notable oxygen dependence. Herein, a concept emphasizing on transition from molecular PSs into semiconductor-like photocatalysts is proposed, which converts the PSs from type II photoreaction to efficient type I photoreaction.
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Angew Chem Int Ed Engl
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Institution Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, P. R. China.
Article Synopsis
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Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, London, W12 0BZ, UK.
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View Article and Find Full Text PDFExploiting the Potential of Iridium(III) -Nitrone Complexes as Phosphorogenic Bifunctional Reagents for Phototheranostics.
J Am Chem Soc
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Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China.
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View Article and Find Full Text PDFHeavy-atom-free π-twisted photosensitizers for fluorescence bioimaging and photodynamic therapy.
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Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87, Umeå, Sweden.
As the field of preclinical research on photosensitizers (PSs) for anticancer photodynamic therapy (PDT) continues to expand, a focused effort is underway to develop agents with innovative molecular structures that offer enhanced targeting, selectivity, activation, and imaging capabilities. In this context, we introduce two new heavy-atom-free PSs, DBXI and DBAI, characterized by a twisted π-conjugation framework. This innovative approach enhances the spin-orbit coupling (SOC) between the singlet excited state (S) and the triplet state (T), resulting in improved and efficient intersystem crossing (ISC).
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