A cytotoxic gold(III) complex of meso-tetraphenylporphyrin ([Au(TPP)]Cl, denoted gold-1a) blocks the self-renewal ability of cancer stem-like cells and shows appealing safety pharmacological profiles in rodents.
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http://dx.doi.org/10.1039/c2cc37366a | DOI Listing |
Chemistry
August 2024
Institute for Chemical Research, Kyoto University, Gokasho Uji, Kyoto, 611-0011, Japan.
Interactions between gold-based materials and dioxygen (O) have motivated researchers to understand reaction mechanisms for O activation by homo- and heterogeneous gold catalysts. In this work, gold(I) porphyrin dinuclear complexes were synthesized with a saddle-distorted porphyrin ligand. The gold(I) porphyrin complexes showed unprecedented O activation in the presence of protic solvents to form gold(III) tetradentate porphyrin complexes.
View Article and Find Full Text PDFACS Appl Mater Interfaces
June 2024
Life and Health Intelligent Research Institute, Tianjin Key Laboratory of Life and Health Detection, Tianjin University of Technology, Tianjin 300384, P. R. China.
Photothermal therapy (PTT) is a promising clinical antitumor strategy. However, local hyperthermia inevitably induces heat damage to adjacent normal tissues, while alternative mild-temperature therapy (MPTT, < 45 °C) is also inefficient due to the overexpressed hyperthermia-induced heat shock proteins (HSPs) by cancer cells. Therefore, developing PTT strategies with minimizing damage to healthy tissues with improved cellular temperature sensitivity is extremely valuable for clinical application.
View Article and Find Full Text PDFChemSusChem
May 2024
Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan.
In dye-sensitized solar cells (DSSCs), flat planar dyes (e. g., highly light-harvesting porphyrins and corroles) with multiple anchoring groups are known to adopt a horizontal orientation on TiO through the multiple binding to TiO.
View Article and Find Full Text PDFIn the context of the development of coordination energy-harvesting systems, the axial bonding of cobalt(II) octakis(3,5-di--butylphenoxy)phthalocyanine (1) with gold(III) 2,3,7,8,12,18-hexamethyl,13,17-diethyl,5-(pyridin-4-yl)- and (2,3,7,8,12,18-hexamethyl,13,17-diethyl,5-(pyridin-3-yl)porphin (2 and 3), the structure, the spectral/electrochemical properties of the resulting donor-acceptor complexes and photoinduced electron transfer in them are studied. The process of the dyad formation passing as self-assembly in the donor-acceptor phthalocyanine-porphyrin systems was explored using UV-Visible, IR, and H NMR spectroscopy and mass spectrometry. The geometric and electronic structures of the dyads were identified using density functional theory (DFT) and time-dependent DFT calculations.
View Article and Find Full Text PDFJ Inorg Biochem
June 2022
Department of Chemistry and Center for Theoretical and Computational Chemistry, University of Tromsø, N-9037 Tromsø, Norway. Electronic address:
Soret-excited resonance Raman spectra (λ 413.1 nm) were acquired for manganese(III) and gold(III) tris(pentafluorophenyl)corrole, each as four different isotopomeric samples: natural abundance, fully pyrrole-N-substituted, fully meso-C-substituted, and fully pyrrole-N-meso-C-substituted. The spectra were modeled with density functional theory-based vibrational analyses, which in general did an excellent job of reproducing both the absolute frequencies and isotope shifts.
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