A gold(III) porphyrin complex as an anti-cancer candidate to inhibit growth of cancer-stem cells.

Chem Commun (Camb)

Department of Chemistry, State Key Laboratory of Synthetic Chemistry, and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong.

Published: May 2013

AI Article Synopsis

  • A gold(III) complex known as [Au(TPP)]Cl (gold-1a) has been found to inhibit the self-renewal capacity of cancer stem-like cells.
  • This compound demonstrates promising pharmacological safety in rodent studies, suggesting it could be a viable option for cancer treatment.
  • The research indicates a potential for gold-1a to target cancer stem cells while minimizing harmful side effects.

Article Abstract

A cytotoxic gold(III) complex of meso-tetraphenylporphyrin ([Au(TPP)]Cl, denoted gold-1a) blocks the self-renewal ability of cancer stem-like cells and shows appealing safety pharmacological profiles in rodents.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c2cc37366aDOI Listing

Publication Analysis

Top Keywords

goldiii porphyrin
4
porphyrin complex
4
complex anti-cancer
4
anti-cancer candidate
4
candidate inhibit
4
inhibit growth
4
growth cancer-stem
4
cancer-stem cells
4
cells cytotoxic
4
cytotoxic goldiii
4

Similar Publications

Interactions between gold-based materials and dioxygen (O) have motivated researchers to understand reaction mechanisms for O activation by homo- and heterogeneous gold catalysts. In this work, gold(I) porphyrin dinuclear complexes were synthesized with a saddle-distorted porphyrin ligand. The gold(I) porphyrin complexes showed unprecedented O activation in the presence of protic solvents to form gold(III) tetradentate porphyrin complexes.

View Article and Find Full Text PDF

Gold(III) Porphyrin-Metal-Polyphenolic Nanocomplexes: Breaking Intracellular Redox Environment for Enhancing Mild-Temperature Photothermal Therapy.

ACS Appl Mater Interfaces

June 2024

Life and Health Intelligent Research Institute, Tianjin Key Laboratory of Life and Health Detection, Tianjin University of Technology, Tianjin 300384, P. R. China.

Photothermal therapy (PTT) is a promising clinical antitumor strategy. However, local hyperthermia inevitably induces heat damage to adjacent normal tissues, while alternative mild-temperature therapy (MPTT, < 45 °C) is also inefficient due to the overexpressed hyperthermia-induced heat shock proteins (HSPs) by cancer cells. Therefore, developing PTT strategies with minimizing damage to healthy tissues with improved cellular temperature sensitivity is extremely valuable for clinical application.

View Article and Find Full Text PDF

In dye-sensitized solar cells (DSSCs), flat planar dyes (e. g., highly light-harvesting porphyrins and corroles) with multiple anchoring groups are known to adopt a horizontal orientation on TiO through the multiple binding to TiO.

View Article and Find Full Text PDF

In the context of the development of coordination energy-harvesting systems, the axial bonding of cobalt(II) octakis(3,5-di--butylphenoxy)phthalocyanine (1) with gold(III) 2,3,7,8,12,18-hexamethyl,13,17-diethyl,5-(pyridin-4-yl)- and (2,3,7,8,12,18-hexamethyl,13,17-diethyl,5-(pyridin-3-yl)porphin (2 and 3), the structure, the spectral/electrochemical properties of the resulting donor-acceptor complexes and photoinduced electron transfer in them are studied. The process of the dyad formation passing as self-assembly in the donor-acceptor phthalocyanine-porphyrin systems was explored using UV-Visible, IR, and H NMR spectroscopy and mass spectrometry. The geometric and electronic structures of the dyads were identified using density functional theory (DFT) and time-dependent DFT calculations.

View Article and Find Full Text PDF

Structure-sensitive marker bands of metallocorroles: A resonance Raman study of manganese and gold corrole derivatives.

J Inorg Biochem

June 2022

Department of Chemistry and Center for Theoretical and Computational Chemistry, University of Tromsø, N-9037 Tromsø, Norway. Electronic address:

Soret-excited resonance Raman spectra (λ 413.1 nm) were acquired for manganese(III) and gold(III) tris(pentafluorophenyl)corrole, each as four different isotopomeric samples: natural abundance, fully pyrrole-N-substituted, fully meso-C-substituted, and fully pyrrole-N-meso-C-substituted. The spectra were modeled with density functional theory-based vibrational analyses, which in general did an excellent job of reproducing both the absolute frequencies and isotope shifts.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!