We used differential time to positivity between central and peripheral blood cultures to evaluate the positive predictive value (PPV) of the National Healthcare Safety Network central line-associated bloodstream infection (CLABSI) surveillance definition among hematology patients with febrile neutropenia. The PPV was 27.7%, which suggests that, when the definition is applied to this population, CLABSI rates will be substantially overestimated.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628695PMC
http://dx.doi.org/10.1086/668431DOI Listing

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