Irrigated radiofrequency ablation catheter and electro-anatomical mapping with computerized tomography integration for renal artery sympathetic denervation.

Despite over 6 decades of progress in the development of pharmacological therapy for hypertension, severe drug-resistant hypertension remains a major problem. Endovascular radiofrequency ablation of the proximal renal arteries has been reported to decrease renal artery sympathetic activity and improve long-term hypertensive control. Existing "approved" catheters for this procedure are solid tip, non-irrigated, and often difficult to steer. The existing technique uses angiography and lends itself to increased risk of renal scarring and possible stenosis. We describe a patient with multi-drug resistant hypertension who underwent catheter ablation of the bilateral renal arteries, using for the first time, an open irrigated cardiac ablation catheter with both electro-anatomical guidance and computerized tomography anatomical integration. We used "off-label" irrigated catheters, which are less prone to overheating and char formation at the catheter-surface interface, thereby decreasing the possibility of distal embolization to the renal parenchyma. The integration of electro-anatomical mapping into this procedure allowed us to avoid inadvertent circumferential ablation of the artery using electro-anatomical mapping may lower the risk of subsequent renal artery stenosis.