AI Article Synopsis
- The study investigates cortisol and DHEA-S hormone levels in post-menopausal women with Fibromyalgia Syndrome (FMS) and their relationship with pain, depression, and quality of life.
- Researchers compared 17 women with FMS to 19 healthy volunteers using pain assessments and psychological scales, along with blood tests for hormone levels.
- Results showed significant differences in pain sensitivity and psychological metrics between the groups, but no notable differences in cortisol levels; however, a potential link between lower DHEA-S levels and higher pain sensitivity was observed in the FMS group.
Article Abstract
Objective: This study aims to assess cortisol and dehydroepiandrosterone sulfate (DHEA-S) levels in post-menopausal women with FMS and correlate it with pain threshold and tolerance, depression and quality of life.
Methods: We conducted a cross sectional observational study of 17 women with FMS (FMS group), and 19 healthy volunteers (CT group). Algometry, the Beck Depression Index (BDI) and Fibromyalgia Impact Questionnaire (FIQ) were used. Blood samples were collected in the morning (8:00-9:30 am) to determine cortisol and DHEA-S plasmatic levels by chemiluminescence.
Results: Significant differences between groups were recorded for pain threshold and tolerance (p< 0.0001), BDI (p< 0.0001) and all FIQ parameters (p< 0.0001). No significant differences in cortisol levels were found between the two groups (p=0.325). In the FMS group, a tangential effect was observed for DHEA-S (p=0.094) and positive correlations were found between DHEA-S, pain threshold (p=0.017) and pain tolerance (p=0.044). No correlation was observed between cortisol and DHEA-S levels and the variables of depression and quality of life for either group.
Conclusions: There seems to be an influence of the decreased levels of DHEA-S and increased pain sensitivity in post-menopausal women with FMS.
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| http://dx.doi.org/10.3233/BMR-2012-0331 | DOI Listing |
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