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Rapid implementation of open-access pandemic education for global frontline healthcare workers.
BMC Res Notes
January 2025
Nurses International, PO Box 114, Anoka, MN, 55303, USA.
Background: The recent global pandemic posed extraordinary challenges for healthcare systems. Frontline healthcare workers required focused, immediate, practical, evidence-based instruction on optimal patient care modalities as knowledge evolved around disease management.
Objective: This course was designed to provide knowledge to protect healthcare workers; combat disease spread; and improve patient outcomes.
INSIGHT: A Tool for Fit-for-Purpose Evaluation and Quality Assessment of Standardized Observational Data Sources for Real World Evidence on Medicine and Vaccine Safety.
Pharmacoepidemiol Drug Saf
January 2025
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Purpose: To describe the development of INSIGHT, a real-world data quality tool to assess completeness, consistency, and fitness-for-purpose of observational health data sources.
Methods: We designed a three-level pipeline with data quality assessments (DQAs) to be performed in ConcePTION Common Data Model (CDM) instances. The pipeline has been coded using R.
Mn-Doped Ni(OH)2 Nanosheets as High-Performance Electrocatalyst for 5-Hydroxymethylfurfural Electrooxidation.
Chem Asian J
January 2025
Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of Education, school of chemistry and chemical engineering, Shanda nan Road 27, 250100, Jinan, CHINA.
Converting 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) via electrooxidation is a sustainable approach for generating high-value chemicals from biomass. This study presents Mn-doped Ni(OH)2 nanosheets as an effective electrocatalyst for HMF electrooxidation. The Mn-doped Ni(OH)2 nanosheets were synthesized through a microwave-assisted deep eutectic solvent (DES) strategy, followed by an alkaline reflux process.
View Article and Find Full Text PDFAI generated synthetic STIR of the lumbar spine from T1 and T2 MRI sequences trained with open-source algorithms.
AJNR Am J Neuroradiol
January 2025
From the Orthopedic Data Innovation Lab (ODIL), Hospital for Special Surgery (A.M.L.S., M.A.F.), Department of Radiology and Imaging, Hospital for Special Surgery Centre (E.E.X, Z.I, E.T.T, D.B.S, J.L.C)and Department of Population Health Sciences, Weill Cornell Medicine (M.A.F), New York, New York, USA.
Background And Purpose: To train and evaluate an open-source generative adversarial networks (GANs) to create synthetic lumbar spine MRI STIR volumes from T1 and T2 sequences, providing a proof-of-concept that could allow for faster MRI examinations.
Materials And Methods: 1817 MRI examinations with sagittal T1, T2, and STIR sequences were accumulated and randomly divided into training, validation, and test sets. GANs were trained to create synthetic STIR volumes using the T1 and T2 volumes as inputs, optimized using the validation set, then applied to the test set.
Natural phenylethanoid glycoside forsythoside A alleviates androgenetic alopecia by selectively inhibiting TRPV3 channels in mice.
Eur J Pharmacol
January 2025
Department of Pharmacology, School of Pharmacy, Qingdao Medical College of Qingdao University, Qingdao, China; Institute of Innovative Drugs, Qingdao University, Qingdao, China.
Dihydrotestosterone (DHT), an androgen derivate, is known to be a key factor involved in androgenetic alopecia. DHT suppresses the growth of outer root sheath cells and induces apoptosis of hair keratinocytes, thereby causing hair follicle miniaturization and hair regrowth inhibition. Forsythoside A, a natural substance derived from Forsythia suspensa, has been shown to reduce DHT-induced apoptosis in human hair cells and suppress hair regrowth inhibition induced by DHT in mice.
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