AI Article Synopsis
- The study explored why schizophrenia patients exhibit a diminished skin flush response to niacin, testing various niacin concentrations and evaluating two specific gene polymorphisms related to inflammatory processes.
- Statistical analysis showed a weak but significant relationship between the studied gene variants and the niacin flush response, with certain genetic alleles linked to higher flush values, though they only explained a small part of the variability in response.
- While the fatty acid content in red blood cells was notably lower in schizophrenia patients, there was no correlation found between these fatty acid levels and sensitivity to niacin.
Article Abstract
We investigated the etiology of the attenuated niacin skin flush response in schizophrenia patients. Skin response to topical niacin of 0.1M, 0.01 M, 0.001 M, and 0.0001 M concentrations was rated using method of volumetric niacin response (VNR) and correlated to two functional A/G polymorphisms in genes: phospholipase A2 group IVA (BanI of the PLA2G4A), and rs689466 of the prostaglandin synthase-2 (PTGS2). We further tested the possible correlation between niacin response and fatty acid (FA) content of red blood cells (RBCs). We detected statistically significant but weak impact of both polymorphisms on niacin flush response in schizophrenia patients. The dosage of the G alleles of both polymorphisms was associated with higher VNR values, although each polymorphic variant accounted for only 1% of the overall flush response variability. Regarding FA content, both n-3 and n-6 polyunsaturated FAs (PUFAs) were significantly reduced in the patient group, but an association with niacin sensitivity was not detected.
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| http://dx.doi.org/10.1016/j.plefa.2012.11.005 | DOI Listing |
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