Background: The aim of this study was to examine whether administration of ulinastatin inhibits pro-inflammatory mediators and ameliorate visceral vasopermeability both in a rat model of major burn, and also in rat cultured endothelial cells stimulated with permeability-evoking mediators.
Methods: Plasma levels of tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), myeloperoxidase (MPO), microvascular permeability, and water content of organ tissues were evaluated in a rodent model of a 55% TBSA full-thickness scald injury. Microvascular permeability was also evaluated with a cultured pulmonary microvascular endothelial cells (PMECs) monolayer after stimulation with trypsin, bradykinin, histamine, prostaglandin E2 and burn serum.
Results: We found that the plasma levels of TNF-α, CRP, MPO, vascular permeability and water content of heart, lung, kidney, and small intestine tissues were significantly increased in animals after scald injury, and administration of ulinastatin lowered the levels TNF-α, CRP, MPO, vascular permeability and water content of those organ tissues. In vitro, ulinastatin lowered the levels of TNF-α, interleukin-6 (IL-6) and attenuated permeability in PMEC monolayers after being stimulated with burn serum or trypsin, but not by bradykinin, histamine or prostaglandin E2.
Conclusions: These results indicate that ulinastatin attenuates the systemic inflammatory response and visceral vasopermeability both in vivo and vitro, and may serve as a therapeutic agent for prevention of systemic inflammatory response and leakage of fluid into tissue after major burn.
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http://dx.doi.org/10.1016/j.burns.2012.11.004 | DOI Listing |
Environ Sci Pollut Res Int
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Lomonosov Moscow State University, Moscow, Russia.
On October 11, 2018, in the Ulytau region of the Republic of Kazakhstan, the Soyuz-FG launch vehicle carrying a crewed MS-10 spacecraft failed. It resulted in the release into the fragile arid ecosystems of rocket propellants, i.e.
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Division of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand.
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January 2025
Research Laboratory of Inorganic Chemical Process Technologies, School of Chemical Engineering, University of Science and Technology, Narmak, Tehran, 1684613114, Iran.
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January 2025
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, 610500, China.
The exploration and development of deep marine shale gas has made significant breakthroughs, but factors influencing gas contents of deep marine shale are elusive, and quantitative prediction methods of gas content needs to be refined urgently. In this study, the deep marine shale of Longmaxi Formation in Luzhou area was taken as an example, vitrinite reflectance analysis, kerogen microscopy experiment, TOC content analysis, mineral composition analysis, gas content measurement, isothermal adsorption experiment, physical property analysis and argon ion polishing scanning electron microscopy experiment were carried out to find out factors affecting the gas content of deep marine shale, and a gas content prediction model has been worked out. Conclusions below have been reached: the content of adsorbed gas is mainly affected by Ro, TOC content, porosity, water saturation, clay mineral content, formation temperature and pressure; the content of free gas is mainly controlled by porosity, water saturation, formation temperature and pressure; according to the prediction models, the adsorbed gas content, free gas content and total gas content of each well were quantitatively calculated, and the study area was divided into Class I (with a total gas content ≥ 11 m/t), Class II (with a total gas content between 9 m/t and 11 m/t), and Class III (with a total gas content < 9 m/t) gas-bearing areas.
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Department of Applied Plant Biology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.
Sweet corn is highly susceptible to water deprivation, making it crucial to identify effective strategies for enhancing its tolerance to water deficit conditions. This study investigates the novel application of Spermine as a bio-stimulant to improve sweet corn (Zea mays L. var.
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