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Diagnostic abnormalities, disease severity and immunotherapy responsiveness in individuals with Down syndrome regression disorder.
Sci Rep
December 2024
Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Introduction: Down Syndrome Regression Disorder (DSRD) is a neuropsychiatric condition causing insomnia, catatonia, encephalopathy, and obsessive-compulsive behavior in otherwise healthy individuals with Down syndrome (DS). Smaller cohorts have identified heterogenous diagnostic abnormalities which have predicted immunotherapy responsiveness although pattern analysis in a large cohort has never been performed.
Methods: A multi-center, retrospective study of individuals with DSRD was performed.
Death and hospital contact in a cohort from Thyborøn-Harboøre an environmentally contaminated site in Denmark.
Sci Rep
December 2024
Omicron, Telefonvej 8D, 2nd, Søborg, 2860, Denmark.
We studied mortality and hospital contact in people from Thyborøn-Harboøre, an environmentally contaminated fishing community on the Danish West Coast. The population and a comparison group from other fishing communities on the Danish West Coast were identified from historical data in the Central Population Register. All persons were followed up for death and hospital contacts to March 2023.
View Article and Find Full Text PDFA Re-Evaluation of the Utility of Symptom Checklist-90-Revised for Measuring the Spectra in the Hierarchical Taxonomy of Psychopathology.
Pediatr Rep
December 2024
Psychology Department, School of Health and Biomedicine, Bundoora Campus, RMIT University, Melbourne, VIC 3000, Australia.
Unlabelled: The present study examines the potential of the Symptom Checklist-90-Revised (SCL-90-R) as a measure for the Hierarchical Taxonomy of Psychopathology (HiTop) model. Two structural models were evaluated. In Model 1, the SCL-90-R dimensions were allocated to somatoform (comprising somatization), internalizing (comprising obsessive-compulsive, interpersonal sensitivity, depression, anxiety, and phobic anxiety), and antagonistic disinhibited (comprising hostility) spectra.
View Article and Find Full Text PDFNegative valence in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium.
Biol Psychiatry
December 2024
Amsterdam UMC, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Compulsivity, Impulsivity and Attention, Amsterdam, The Netherlands.
Objective: Obsessive-compulsive disorder (OCD) is associated with altered brain function related to processing of negative emotions. To investigate neural correlates of negative valence in OCD, we pooled fMRI data of 633 individuals with OCD and 453 healthy controls from 16 studies using different negatively-valenced tasks across the ENIGMA-OCD Working-Group.
Methods: Participant data were processed uniformly using HALFpipe, to extract voxelwise participant-level statistical images of one common first-level contrast: negative vs.
Therapeutic DBS for OCD Suppresses the Default Mode Network.
Hum Brain Mapp
December 2024
Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) is a circuit-based treatment for severe, refractory obsessive-compulsive disorder (OCD). The therapeutic effects of DBS are hypothesized to be mediated by direct modulation of a distributed cortico-striato-thalmo-cortical network underlying OCD symptoms. However, the exact underlying mechanism by which DBS exerts its therapeutic effects still remains unclear.
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