Extraocular sebaceous carcinoma (ESC) is a rare, aggressive malignant tumor that originates from the adnexal epithelium of the sebaceous gland. We present herein one of the largest cases reported in the literature until now. We also review briefly the relevant aspects including clinical presentation, differential diagnosis, histopathological features, inmunohistochemical profile, and therapeutic options.
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Sebaceous Carcinoma in the Right Inguinal Region with Multiple Metastases and a Poor Prognosis: A Case Report.
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- * Conducted on 39 SC patients, it found that various nuclear receptors were present in tumor cells, with glucocorticoid receptors the most common, while specific glucose transporters showed high expression, indicating potential targets for therapy.
- * Key findings suggest that hormonal and metabolic factors influence SC progression, identifying low androgen receptor levels and high monocarboxylate transporter 1 expression as indicators of poor survival outcomes, highlighting their potential as therapeutic targets.
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