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Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer's disease.
Alzheimers Res Ther
January 2025
Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA.
Background: PSEN1, PSEN2, and APP mutations cause Alzheimer's disease (AD) with an early age at onset (AAO) and progressive cognitive decline. PSEN1 mutations are more common and generally have an earlier AAO; however, certain PSEN1 mutations cause a later AAO, similar to those observed in PSEN2 and APP.
Methods: We examined whether common disease endotypes exist across these mutations with a later AAO (~ 55 years) using hiPSC-derived neurons from familial Alzheimer's disease (FAD) patients harboring mutations in PSEN1, PSEN2, and APP and mechanistically characterized by integrating RNA-seq and ATAC-seq.
Cognitive and preference disparities of Chinese consumers regarding the disclosure of unsafe food recall information.
Front Public Health
January 2025
School of Economics, Anhui University of Finance and Economics, Bengbu, China.
Introduction: Information disclosure is important in promoting unsafe food recalls and reducing potential food safety risks. However, the governance of unsafe food recall information in China is distorted, leading to cognitive dissonance in Chinese consumers' perceptions of unsafe food recall information. Focusing on consumers' search and cognitive costs, this study suggests that market regulators should proactively and fully disclose unsafe food recall information to satisfy consumers' needs and preferences for recall information, thereby optimizing consumer perceptions and facilitating the improvement of the information governance system for unsafe food recalls.
View Article and Find Full Text PDFClose relationship partners of impartial altruists do not report diminished relationship quality and are similarly altruistic.
Commun Psychol
December 2024
Department of Psychology, Georgetown University, Washington, DC, USA.
Impartial altruism is often considered a moral ideal but is rare in practice. Instead, generosity typically decreases as social distance increases, a phenomenon termed social discounting. Most people prefer this partiality in their close relationships and view impartial altruists as poorer relationship partners.
View Article and Find Full Text PDFDo directed and non-directed oocyte donors differ regarding their motives, ambivalence, satisfaction and openness about donating?
Reprod Biomed Online
September 2024
Department of Psychology, Umeå University, Umeå, Sweden.
Research Question: Do directed oocyte donors differ from non-directed identity-release oocyte donors regarding pre-donation motives and ambivalence, and post-donation satisfaction and openness?
Design: The study is part of the longitudinal Swedish Study on Gamete Donation where consecutive samples of identity-release gamete donors at seven Swedish University Hospitals were approached during a 3-year period (2005-2008). The participants of the current study were 16 women who donated oocytes to family members or friends (directed donation) and 123 women who donated to unknown recipients (non-directed donation). Survey data on motivation, ambivalence, post-donation satisfaction and openness were collected at five time points between acceptance as a donor and 14-17 years post-donation.
How does dispositional mindfulness foster prosocial behavior? A cross-cultural study of empathy's mediating role and cultural moderation.
Front Psychol
November 2024
Department of Psychology, Guangxi Normal University, Guilin, China.
Article Synopsis
- The study explores how dispositional mindfulness (DM) affects prosocial behavior across different cultures, focusing on the roles of empathy dimensions and cultural backgrounds.
- It involved 683 university students from China and Indonesia, who completed various scales to measure mindfulness, empathy, and altruism, with analysis methods used to examine mediation and moderation.
- Results showed that Chinese participants displayed higher DM levels and that empathy dimensions like perspective taking and empathic concern mediated the relationship between DM and prosocial behavior, particularly toward family, friends, and strangers, with cultural differences influencing these effects.
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