AI Article Synopsis
- Drug-induced hypersensitivity syndrome (DIHS) or DRESS is a severe reaction often characterized by skin eruptions and effects on other organ systems, typically linked to certain medications like carbamazepine.
- This report discusses a unique case of DIHS/DRESS triggered by carbamazepine, which presented with acute generalized pustular eruptions and also affected skeletal muscles.
- The findings highlight that while pustular eruptions are uncommon in DIHS/DRESS, they can occur with carbamazepine use, and it’s crucial to consider drug reactions when such symptoms present, even when the skin lesions resemble more typical pustular conditions.
Article Abstract
Drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe reaction usually associated with maculopapular eruptions and systemic involvement. Here we report the first case, to our knowledge, of DIHS/DRESS due to carbamazepine with acute generalized pustular bacterid-like (AGPB-like) eruptions and skeletal muscle involvement. Reviewing our case and the published work, we discuss pustular-type DIHS/DRESS which, in most cases, involves acute generalized exanthematous pustulosis (AGEP)-like skin eruptions in response to carbamazepine. Pustular eruptions may appear in relatively few cases of DIHS/DRESS, in particular, when the causative drug is carbamazepine and, even in cases of intractable pustular bacterid-like eruptions, a reaction to a drug should be suspected. Skeletal muscle involvement may be associated with DIHS/DRESS as one of its systemic manifestations.
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| http://dx.doi.org/10.1111/1346-8138.12028 | DOI Listing |
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