An efficient total synthesis of (-)-epothilone B has been achieved in ca. 8% yield over 11 steps from 9 (or 10 steps from 7/8), which features a bissiloxane-tethered ring closing metathesis reaction to approach the trisubstituted (Z) double bond and forms a new basis for further development of an industrial process for epothilone B and ixabepilone.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol303148g | DOI Listing |
Publication Analysis
Top Keywords
efficient total
8
total synthesis
8
synthesis --epothilone
8
--epothilone efficient
4
--epothilone achieved
4
achieved yield
4
yield steps
4
steps steps
4
steps 7/8
4
7/8 features
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!