We measure the statistics of phase locking levels of coupled fiber lasers with fluctuating cavity lengths. We found that the measured distribution of the phase locking level of such coupled lasers can be described by the generalized extreme value distribution. For large number of lasers the distribution of the phase locking level can be approximated by a Gumbel distribution. We present a simple model, based on the spectral response of coupled lasers, and the calculated results are in good agreement with the experimental results.
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http://dx.doi.org/10.1103/PhysRevE.86.041142 | DOI Listing |
Bioanalysis
January 2025
Bioanalysis Discovery & Development Sciences, Johnson & Johnson, Spring House, PA, USA.
Background: Most oligonucleotide bioanalytical assays currently only quantify the pharmacologically-active antisense strand, though there have been recent efforts to simultaneously quantify the sense strand using hybridization ELISA or solid phase extraction LC-MS. Hybrid LC-MS, which offers both high sensitivity and specificity unlike the currently used platforms, has not been applied to quantify both siRNA strands simultaneously.
Materials & Methods: A hybrid LC-MS assay utilizing LNA capture probes was developed and applied to quantify both strands of a 21-mer lipid-conjugated siRNA (SIR-3) using tandem mass spectrometry (MS/MS).
J Neural Eng
January 2025
Weldon School of Biomedical Engineering, Purdue University, 723 W. Michigan St., Indianapolis, Indiana, 46202, UNITED STATES.
Objective: Direct electrical neurostimulation using continuous sinusoidal low frequency alternating currents (LFAC) is an emerging modality for neuromodulation. As opposed to the traditional rectangular pulse stimulation, there is limited background on the characteristics of peripheral nerves responses to sinusoidal LFAC stimulation; especially within the low frequency range (<50Hz). In this study, we demonstrate LFAC activation as a means to activate motor nerves by direct bipolar nerve stimulation via cuff electrodes, and characterize the factors of activation.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Instituto de Ciencia de Materiales de Madrid, CSIC, E-28049 Madrid, Spain.
We address the precise determination of the phase diagram of magic angle twisted bilayer graphene under hydrostatic pressure within a self-consistent Hartree-Fock method in real space, including all the remote bands of the system. We further present a novel algorithm that maps the full real-space density matrix to a 4×4 density matrix based on a SU(4) symmetry of sublattice and valley degrees of freedom. We find a quantum critical point between a nematic and a Kekulé phase, and show also that our microscopic approach displays a strong particle-hole asymmetry in the weak coupling regime.
View Article and Find Full Text PDFPrevious studies have shown that perceptual performance can be modulated at specific frequencies phase-locked to self-paced motor actions, but findings have been inconsistent. To investigate this effect at the population level, we tested 50 participants who performed a self-paced button press followed by a threshold-level detection task, using both fixed- and random-effects analyses. Contrary to expectations, the aggregated data showed no significant action-related modulation.
View Article and Find Full Text PDFWave mixing (WM) techniques are crucial for applications such as supercontinuum generation, frequency conversion, and high-dimensional quantum encoding. However, their efficiency is often limited by complex phase-matching requirements, and current insights into phase-matching mechanisms for high-order WM remain limited. To address this, compact optical path configurations with high-peak-power, synchronous, multicolor ultrafast laser sources are needed to enhance high-order wave-mixing efficiency.
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