Objective: To analyze the chemical constituents of petroleum fraction of Aconitum taipeicum.
Methods: The methanol extract of Aconitum taipeicum were extracted by petroleum and then analyzed by GC-MS. The compounds were quantitatively determined by normalization method.
Results: Twenty eight compounds were separated and identified. Most of them were alkane, fat acids and their esters and alkenes. The Nonacosane covered 13.057% of the total peaks, while 19-methyl-18,21-Hexatriacontanediether 8.180%, Ethylen eglycol monooctadecy ether 7.851%, 3,7,11,15-Tetramethyl-2-hexadecen-1-ol 7.805%, Metahyl Palmitate 6.676% and so on.
Conclusion: This is the first report of constituents from the flower, stem and leaf of Aconitum taipeicum. The results will provide foundation for further exploitation and use of Aconitum taipeicum.
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Phytochemistry
June 2023
China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China. Electronic address:
Aconicumines A-D, an advanced class of norditerpenoid alkaloids, and seven known alkaloids, were isolated from Aconitum taipaicum Hand.-Mazz. (Ranunculaceae).
View Article and Find Full Text PDFPlants (Basel)
November 2019
School of Science and Technology, Georgia Gwinnett College, Lawrenceville, GA 30043, USA.
Three species (, , and ) of the tribe Delphinieae (Ranunculaceae) were examined using scanning electron microscopy and histological methods. The results showed that members of Delphinieae differ from their polysymmetrical relatives by four unique features: (1) a spiral phyllotaxis of their perianth and stamens, and a series of carpels, which initiated superficially in a whorl-liked arrangement; (2) sepal 2 being the largest one among the five sepals and becoming helmet-shaped or having a spur; (3) petals 2 and 5 initiated adaxially of sepal 2 and also becoming spurred; and (4) the monosymmetry of the first flower becoming established when sepal 2 becomes the largest. Major differences among the species include the timing of development of the second series; the fusion of two petals into a single one in ; and, during early developmental stages, the two young spurred petals giving rise to a stalk and two bulges in , a single bulge in , or an arch blade in .
View Article and Find Full Text PDFNat Prod Res
January 2018
d School of International Education , Xi'an Jiaotong University, Xi'an , China.
A concise total synthesis of a naturally occurring 3-isopropyl-tetrahydropyrrolo[1, 2-a]pyrimidine-2, 4(1H, 3H)-dione (ITPD) isolated from Aconitum taipeicum with a three-step approach was depicted in this study for the first time. Two key intermediates, diethyl isopropylmalonate (2) and pyrrolidin-2-amine (3), being synthsesised separately from initial diethyl malonate (4) and 3, 4-dihydro-2H-pyrrol-5-amine (5), were utilised to obtain the compound entitled ITPD. ITPD showed a promising anticancer activity in vitro on SMMC-7721 cell lines.
View Article and Find Full Text PDFJ BUON
November 2014
School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
Purpose: To investigate whether taipeinine A (JNQ2), a C19-diterpenoid alkaloid prepared from the roots of Aconitum taipeicum, has anticancer effects on hepatocellular carcinoma (HCC) and to study its probable anticancer mechanisms.
Methods: JNQ2 activities were assessed on human HCC cell line (HepG2) by proliferative assay, cell cycle arrest assay, apoptosis analysis, cell invasion assay and Western blot analysis.
Results: The antitumor activity tests showed that JNQ2 inhibited the proliferation of HepG2 cells in a dose- and time-dependent manner and blocked the cell cycle at the G1/S phase.
Zhong Yao Cai
May 2012
Faculty of Pharmacy of School of Medicine, Xi'an Jiao tong University, Xi'an 710061, China.
Objective: To analyze the chemical constituents of petroleum fraction of Aconitum taipeicum.
Methods: The methanol extract of Aconitum taipeicum were extracted by petroleum and then analyzed by GC-MS. The compounds were quantitatively determined by normalization method.
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