AI Article Synopsis
- The study examines how specific gene variations in CD36 relate to the effectiveness of photodynamic therapy (PDT) in treating polypoidal choroidal vasculopathy (PCV).
- Out of 137 PCV patients treated with PDT, those who improved visually after 6 months (responders) showed different genetic markers compared to those who did not (non-responders), particularly with the SNP rs3173798.
- The findings suggest that carrying a specific variant (C allele) in rs3173798 may lead to poorer visual outcomes after PDT, indicating a potential genetic influence on treatment response in PCV patients.
Article Abstract
Purpose: To clarify the association between cluster of differentiation 36 (CD36) gene polymorphisms and the response to photodynamic therapy (PDT) in polypoidal choroidal vasculopathy (PCV).
Methods: One hundred and thirty-seven patients with PCV were enrolled. The patients were treated with PDT and followed up for more than 6 months. Retreatments were performed every 3 months as needed based on findings from angiography. Patients who showed an improvement in their best-corrected visual acuity at 6 months post-PDT were classified as PDT responders, and the others were defined as non-responders. For the 73 responders and 64 non-responders, 19 single nucleotide polymorphisms (SNPs) across the CD36 region were genotyped using the TaqMan assay. We analyzed the association between these variants and the visual outcomes of PDT.
Results: The allelic frequencies of the SNPs rs3211851, rs3173798, and rs3211908 showed nominally significant differences between the PDT responders and non-responders. Genotype association analysis revealed a significant association of SNP rs3173798 with the visual outcome of PDT in a dominant model. The presence of the C allele in rs3173798 was significantly associated with a poor response to PDT after multivariate logistic regression analysis with clinical pre-PDT parameters. The mean best-corrected visual acuity in the group with the TT genotype of rs3173798 was significantly improved over 12 months of follow-up after the initial PDT.
Conclusions: The coding variants in CD36 are possibly associated with the visual outcome of PDT in patients with PCV.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513185 | PMC |
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