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UV Light Exposure Induces a Type I Interferon Dependent Activation and Migration of Inflammatory Dendritic Cells to Local Lymph Nodes.
Arthritis Rheumatol
January 2025
Division of Rheumatology, Department of Medicine.
Objective: Photosensitivity occurs in ~75% of lupus patients. Although ultraviolet light radiation (UVR) stimulates Type I interferon (IFN-I) in the skin, how UVR induced skin inflammation leads to downstream effects is poorly understood. Tissue inflammation causes DC to migrate from organs to draining lymph nodes (dLN) including a recently identified inflammatory DC subset (inf cDC2) that are potent antigen presenting cells.
View Article and Find Full Text PDFA novel multilayer antimicrobial urinary catheter material with antimicrobial properties.
Mater Adv
December 2024
Cardiff University School of Pharmacy and Pharmaceutical Sciences, Redwood Building King Edward VII Ave Cardiff CF10 3NB UK
Urinary catheters are commonly used in medical practice to drain and monitor urine of patients. However, urinary catheterisation is associated with the risk of developing catheter-associated urinary tract infections (CAUTIs), which can result in life-threatening sepsis that requires antibiotics for treatment. Using the layer-by-layer (LbL) technique, we assembled a multilayer catheter comprising nine quadruple layers (9QL) of alginate, chlorhexidine (CHX), alginate and poly(β-amino ester) (PBAE) built upon an amino-functionalised silicone.
View Article and Find Full Text PDFEnhanced Drive Current in 10 nm Channel Length Gate-All-Around Field-Effect Transistor Using Ultrathin Strained Si/SiGe Channel.
Micromachines (Basel)
November 2024
Sede Vallenar, Universidad de Atacama, Costanera 105, Vallenar 1612178, Chile.
The continuous scaling down of MOSFETs is one of the present trends in semiconductor devices to increase device performance. Nevertheless, with scaling down beyond 22 nm technology, the performance of even the newer nanodevices with multi-gate architecture declines with an increase in short channel effects (SCEs). Consequently, to facilitate further increases in the drain current, the use of strained silicon technology provides a better solution.
View Article and Find Full Text PDFDeveloping a framework for tracking antimicrobial resistance gene movement in a persistent environmental reservoir.
NPJ Antimicrob Resist
December 2024
Biocomplexity Institute, University of Virginia, Charlottesville, VA USA.
Mobile genetic elements are key to the global emergence of antibiotic resistance. We successfully reconstructed the complete bacterial genome and plasmid assemblies of isolates sharing the same carbapenemase gene to understand evolution over time in six confined hospital drains over five years. From 82 isolates we identified 14 unique strains from 10 species with 113 carrying plasmids across 16 distinct replicon types.
View Article and Find Full Text PDFExploring the binomial BALB/c-Leishmania (Viannia) braziliensis model to assess the in vivo performance of Thor strain subpopulations.
Exp Parasitol
December 2024
Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas, Rio de Janeiro, RJ, Brazil. Electronic address:
Article Synopsis
- Leishmania (Viannia) braziliensis causes various types of leishmaniasis, and the study investigates how different subpopulations (Thor03, Thor10, Thor22) affect disease progression in BALB/c mice.
- The research found that after three weeks of infection, Thor03 and Thor10 led to larger lesions and influenced immune response markers, showing lower IL-12 and TNF levels, while Thor10 had the highest IL-10 levels.
- The study concluded that these subpopulations might lead to mild footpad lesions but can persist in lymph nodes, highlighting differences in infection patterns and immune responses among the subpopulations.
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