A route is described for the enantioselective synthesis of (R)-(-)-complanine, a marine natural product isolated from Eurythoe complanata, and known to be a causative agent in inflammation. An organocatalytic, asymmetric oxyamination of a homoconjugated all-Z-dienal intermediate provides versatile and efficient access to the natural product.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511001 | PMC |
| http://dx.doi.org/10.3762/bjoc.8.192 | DOI Listing |
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