A facile no-carrier-added one pot micro-molar scale radiolabelled synthesis of 2-[(14)C]-uracil from [(14)C]-urea and propiolic acid in the presence of polyphosphoric acid (PPA) with an yield of 48.33% and with radiochemical purity of 98% is reported in this paper.
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http://dx.doi.org/10.1016/j.apradiso.2012.10.008 | DOI Listing |
Angew Chem Int Ed Engl
April 2015
Department of Chemistry, Princeton University, Princeton NJ 08544 (USA).
We describe the first catalytic decarboxylative fluorination reaction based on the nucleophilic fluoride ion. The reported method allows the facile replacement of various aliphatic carboxylic acid groups with fluorine. Moreover, the potential of this method for PET imaging has been demonstrated by the successful (18) F labeling of a variety of carboxylic acids with radiochemical conversions up to 50 %, representing a targeted decarboxylative (18) F labeling method with no-carrier-added [(18) F]fluoride.
View Article and Find Full Text PDFJ Am Chem Soc
May 2014
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
We describe the first late-stage (18)F labeling chemistry for aliphatic C-H bonds with no-carrier-added [(18)F]fluoride. The method uses Mn(salen)OTs as an F-transfer catalyst and enables the facile labeling of a variety of bioactive molecules and building blocks with radiochemical yields (RCY) ranging from 20% to 72% within 10 min without the need for preactivation of the labeling precursor. Notably, the catalyst itself can directly elute [(18)F]fluoride from an ion exchange cartridge with over 90% efficiency.
View Article and Find Full Text PDFAppl Radiat Isot
February 2013
Radio Labelling Laboratory, Ogene Systems (I) Pvt. Ltd., #11-6-56, GSR Estates, Balanagar, Hyderabad 500037, Andhra Pradesh, India.
A facile no-carrier-added one pot micro-molar scale radiolabelled synthesis of 2-[(14)C]-uracil from [(14)C]-urea and propiolic acid in the presence of polyphosphoric acid (PPA) with an yield of 48.33% and with radiochemical purity of 98% is reported in this paper.
View Article and Find Full Text PDFNucl Med Biol
October 2004
Departments of Chemistry and Radiology, University of Tennessee, Knoxville, TN 37996-1600, USA.
A simple, straightforward radioiodination procedure has been developed that is ideal for use in the construction of radioiodination kits. Isolation of no-carrier-added radioiodinated products from the ionic precursors is readily achieved using simple Sep-Pak filtrations.
View Article and Find Full Text PDFInt J Nucl Med Biol
June 1986
The preparation of radioiodinated 1-(diethylaminopropyl)-4-phenylpiperazine, an analog of HIPDM, and its tissue distribution in rats are described. The precursor undergoes facile electrophilic radioiodination with radionuclides of iodine at the no-carrier-added level to give isolated yields in the 69-85% range. Biodistribution studies indicate that the radiochemical is well extracted by the brain (1.
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