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Atypical presentation of Lambert-Eaton myasthenic syndrome associated with oesophageal squamous cell carcinoma.
BMJ Case Rep
March 2025
Department of Neurology No. 2, Nicolae Testemițanu State University of Medicine and Pharmacy, Chisinau, Moldova (the Republic of).
Lambert-Eaton myasthenic syndrome (LEMS) is a rare neuromuscular junction (NMJ) disorder which is categorised as either paraneoplastic or primary autoimmune. In both forms, auto-antibodies target voltage-gated calcium channels at the presynaptic level of the NMJ. Paraneoplastic LEMS is most commonly associated with small cell lung cancer (SCLC), but it can also be caused by other malignancies.
View Article and Find Full Text PDFAntibody-positive paraneoplastic neurological syndromes associated with immune checkpoint inhibitors: a systematic review.
J Neurol
March 2025
Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Background And Objectives: This study aimed to describe the clinical and prognostic characteristics of antibody-positive paraneoplastic neurological syndrome (PNS) associated with immune checkpoint inhibitors (ICIs).
Methods: We conducted a systematic review of relevant publications in PubMed and Embase from inception to December 2023. Patients with positive anti-neuronal antibodies who had a definite, probable, or possible diagnosis of PNS based on the 2021 PNS-Care Score criteria were included.
Prevalence and incidence rates of 17 neuromuscular disorders: An updated review of the literature.
J Neuromuscul Dis
March 2025
Department of Neurology, Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.
Background: Epidemiological frequency measures serve as reference point for patients, clinicians, researchers, and policymakers. Previously, we published a comprehensive review of the literature with prevalence and incidence rates for thirty neuromuscular disorders frequently encountered in the neuromuscular clinic. No meta-analyses were available at the time.
View Article and Find Full Text PDFType 2 Respiratory Failure as an Initial Manifestation of Lambert-Eaton Myasthenic Syndrome Complicated by Paraneoplastic Autoimmune Encephalitis.
Cureus
January 2025
Department of Neurology, Kobe City Medical Center General Hospital, Kobe, JPN.
Lambert-Eaton myasthenic syndrome (LEMS) is a paraneoplastic or autoimmune neuromuscular disorder that typically presents with limb weakness or autonomic dysfunction. Here, we report a rare case of LEMS with acute type 2 respiratory failure as the initial symptom. A 79-year-old woman was admitted with acute disturbance of consciousness and type 2 respiratory failure.
View Article and Find Full Text PDFPrimary Sjogren's Disease Coexisting With Myasthenia Gravis: Two Distinct Autoimmune Diseases Successfully Treated With a Rituximab-Based Induction Regimen.
Cureus
January 2025
Internal Medicine, Caritas Hospital and Institute of Health Sciences, Kottayam, IND.
Primary Sjögren's syndrome (pSS) and myasthenia gravis (MG) are autoimmune diseases and are rarely reported in coexistence. MG is a chronic autoimmune neuromuscular disease where antibodies bind to acetylcholine receptors or to functionally related molecules in the postsynaptic membrane, weakening the skeletal muscles and causing diplopia, ptosis, and difficulty in breathing and swallowing. In this report, we discuss the case of a 43-year-old female patient who presented with dry eyes, weight loss, fatigue, ptosis, dysarthria, and quadriparesis, which ultimately led to the diagnosis of pSS and MG.
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