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Identifying 10-year cumulative incidence and risk of revision following total hip arthroplasty in patients with and without a diagnosis of human immunodeficiency virus.
Hip Int
December 2024
Department of Orthopaedic Surgery, Virginia Commonwealth University Health, Richmond, VA, USA.
Introduction: Prior studies have shown human immunodeficiency virus (HIV) may be a risk factor for early revision following THA, but little data exists looking at long-term implant survivorship. Therefore, the purpose of this study was to compare the 10-year cumulative incidence rate for revision following THA in patients with and without HIV.
Methods: A retrospective cohort analysis of patients with HIV undergoing elective THA was conducted using a national database.
A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies.
Cell Rep
December 2024
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA. Electronic address:
Antibodies that target the gp120-gp41 interface of the HIV-1 envelope (Env) trimer comprise a commonly elicited category of broadly neutralizing antibodies (bNAbs). Here, we isolate and characterize VRC44, a bNAb lineage with up to 52% neutralization breadth. The cryoelectron microscopy (cryo-EM) structure of antibody VRC44.
View Article and Find Full Text PDFPerceived impact of the COVID-19 pandemic and government restrictions on the lives of young adults living with HIV in Kisumu, Kenya.
PLOS Glob Public Health
December 2024
ICAP at Columbia University, Mailman School of Public Health, New York, New York, United States of America.
Young adults with HIV (YAHIV) may be particularly vulnerable to the impact of the COVID-19 pandemic. In this context, associated mitigation measures among YAHIV can adversely impact fragile social and economic systems. We examined the impact of the pandemic and related government-mandated restrictions among YAHIV in Kisumu, Kenya.
View Article and Find Full Text PDFImproving Diversity in Learning Activities in a Teaching Curriculum in Higher Medical Education.
J Med Educ Curric Dev
December 2024
Department of Obstetrics and Gynaecology, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
The growing demand for medical professionals in undergraduate and graduate/postgraduate medical education to attain comprehensive health training has not abated and necessitates the development of curricula encompassing relevant issues pertaining to clinical practice as well as the educational context. Therefore, diversity in learning activities should be embedded in a teaching curriculum to achieve the required competencies. This includes considering at least the following during the design and analysis of a teaching curriculum: Harden's ten questions to be posed when designing a curriculum; Canadian Medical Education Directives for Specialists (CanMEDS) competency framework which has been approved by the Royal College of Physicians and Surgeons of Canada; 21st-century skills; Diana Laurilliard's conversational framework; and general quality measures to improve diversity in a teaching curriculum.
View Article and Find Full Text PDFAtypical presentation of Kaposi sarcoma in an HIV-negative patient: a case report and comprehensive literature review.
Ann Med Surg (Lond)
December 2024
Faculty of Medicine, Palestine Polytechnic University, Hebron, Palestine.
Introduction: Kaposi's sarcoma (KS) is a systemic disease that is marked by the presence of neoplastic lesions caused by human herpesvirus-8 (HHV-8) infections. KS usually impacts people with weakened immune systems, although there have been a few cases of it occurring in individuals with normal immune function. Medical records and histopathological slides of the case were retrospectively reviewed.
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