Castleman's disease (CD) is a rare lymphoproliferative disease characterized by angiofollicular lymph node hyperplasia. The case of a 74-year-old man with multicentric CD of the plasma cell type is described. The imaging findings on diffusion-weighted whole-body imaging with background body signal suppression at diagnosis and after treatment are reported.
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Introduction Tumor staging is essential for determining treatment strategies and predicting prognosis in cancer patients. Accurate imaging techniques are critical for staging, metastasis screening, treatment response assessment, and recurrence detection. Objective In this prospective study, we aimed to compare the sensitivity of whole-body diffusion-weighted imaging (WB-DWI) with positron emission tomography/computed tomography (PET/CT) in detecting metastases.
View Article and Find Full Text PDFImaging using diffusion-weighted whole-body imaging with background signal suppression for methotrexate-associated lymphoproliferative disorder: A case report.
Mod Rheumatol Case Rep
December 2024
Department of Orthopaedic Surgery, Tokyo Women's Medical University, Tokyo, Japan.
Patients with rheumatoid arthritis (RA) receiving immunosuppressive therapy including methotrexate (MTX), are at risk of developing lymphoproliferative disorder (LPD). Herein, we report the case of a 61-year-old man who has been treated with MTX and sulfasalazine for seropositive RA since the age of 52. He underwent diffusion-weighted whole-body imaging with background signal suppression (DWIBS), which revealed high-intensity lesions in the affected lymph nodes of the cervical, clavicular, and axillary regions.
View Article and Find Full Text PDFQuantification of breast biopsy clip marker artifact on routine breast MRI sequences: a phantom study.
Eur Radiol Exp
November 2024
Department of Radiology, Medical University Innsbruck, Innsbruck, Austria.
Background: To investigate the artifact sizes of four common breast clip-markers on a standard breast magnetic resonance imaging (MRI) protocol in an in vitro phantom model.
Methods: Using 1.5-T and 3-T whole-body scanners with an 18-channel breast coil, artifact dimensions of four breast biopsy markers in an agarose-gel phantom were measured by two readers on images obtained with the following sequences: T2-weighted fast spin-echo short inversion time fat-suppressed inversion-recovery with magnitude reconstruction (T2-TIRM); T1-weighted spoiled gradient-echo with fat suppression (T1_FL3D), routinely used for dynamic contrast-enhanced imaging; diffusion-weighted imaging (DWI), including a readout segmented echo-planar imaging (RESOLVE-DWI) and echo-planar imaging sequence (EPI-DWI).
Enhancing the diagnostic capacity of [F]PSMA-1007 PET/MRI in primary prostate cancer staging with artificial intelligence and semi-quantitative DCE: an exploratory study.
EJNMMI Rep
November 2024
Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69210, Heidelberg, Germany.
Background: To investigate the ability of artificial intelligence (AI)-based and semi-quantitative dynamic contrast enhanced (DCE) multiparametric MRI (mpMRI), performed within [F]-PSMA-1007 PET/MRI, in differentiating benign from malignant prostate tissues in patients with primary prostate cancer (PC).
Results: A total of seven patients underwent whole-body [F]-PSMA-1007 PET/MRI examinations including a pelvic mpMRI protocol with T2w, diffusion weighted imaging (DWI) and DCE image series. Conventional analysis included visual reading of PET/MRI images and Prostate Imaging Reporting & Data System (PI-RADS) scoring of the prostate.
Giving the prostate the boost it needs: Spiral diffusion MRI using a high-performance whole-body gradient system for high b-values at short echo times.
Magn Reson Med
March 2025
Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK.
Article Synopsis
- The study focuses on improving prostate diffusion MRI (dMRI) by using strong gradients and single-shot spiral readouts to enhance image quality amidst low signal-to-noise ratios (SNR) and distortions.
- They utilized an advanced encoding model for image reconstruction, testing it on both phantoms and human subjects, including healthy volunteers and prostate cancer patients.
- Results showed that this method yielded high-quality prostate images with a significant SNR increase (up to 45%) compared to conventional techniques, highlighting the advantages of spirals over traditional EPI imaging.
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