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| http://dx.doi.org/10.1172/JCI67553 | DOI Listing |
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miR-224-5p alleviates preeclampsia-like mouse symptoms by targeting PANX1 to inhibit ferroptosis in trophoblast cells.
Placenta
December 2024
Department of Obstestrics, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, Xinjiang, China. Electronic address:
Preeclampsia (PE) is a high morbidity and lethality disease specific to pregnancy, and insufficient placental trophoblast invasion acts as a crucial factor contributing to PE development. The present study investigated the function and potential mechanism of microRNA (miR)-224-5p within PE. In the study, miR-224-5p expression was reduced within placental tissue samples of the PE mouse model and PE cell model.
View Article and Find Full Text PDFChronic dietary exposure to glyphosate-induced connexin 43 autophagic degradation contributes to blood-testis barrier disruption in roosters.
Sci Total Environ
November 2024
College of Veterinary Medicine, Shandong Provincial Key Laboratory of Zoonoses, Shandong Agricultural University, 7 Panhe Street, Tai'an City, Shandong Province 271017, China. Electronic address:
Article Synopsis
- Glyphosate (GLY) is the most widely used herbicide, but its chronic exposure leads to significant ecological pollution and male reproductive toxicity in roosters remains unclear.
- In studies, chronic GLY exposure was found to cause testicular damage and down-regulation of the gap junction gene Connexin 43 (Cx43), essential for the blood-testis barrier (BTB).
- The degradation of Cx43 was linked to autophagy activation triggered by GLY's interaction with estrogen receptor alpha (ER-α), demonstrating a mechanism for reproductive toxicity in avian species.
Calcium Regulation of Connexin Hemichannels.
Int J Mol Sci
June 2024
Veneto Institute of Molecular Medicine (VIMM), Via Orus 2, 35129 Padova, Italy.
Article Synopsis
- Connexin hemichannels (HCs) are crucial for communication between mammalian cells, as they can form gap junctions and exchange various messenger molecules like ATP and glutamate between the cytoplasm and the external environment.
- The opening of these HCs is influenced by the concentration of calcium ions (Ca) inside and outside the cell, which act as triggers and modulators for HC function, indicating the presence of at least two distinct calcium sensors.
- Abnormal regulation of HCs by calcium is linked to several diseases, suggesting that a balanced calcium sensitivity is essential for normal HC function, highlighting the need for further research to understand how changes in calcium levels affect HCs and potential therapeutic targets.
Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death.
J Lipid Res
July 2024
Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Taikang Center for Life and Medical Sciences, Taikang Medical School, Wuhan University, Wuhan, China. Electronic address:
Sterol-regulatory element binding proteins (SREBPs) are a conserved transcription factor family governing lipid metabolism. When cellular cholesterol level is low, SREBP2 is transported from the endoplasmic reticulum to the Golgi apparatus where it undergoes proteolytic activation to generate a soluble N-terminal fragment, which drives the expression of lipid biosynthetic genes. Malfunctional SREBP activation is associated with various metabolic abnormalities.
View Article and Find Full Text PDFGJA4 expressed on cancer associated fibroblasts (CAFs)-A 'promoter' of the mesenchymal phenotype.
Transl Oncol
August 2024
Department of Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, PR China; Jiangsu Province Key Laboratory of Tumor Systems Biology and Chinese Medicine, Nanjing, Jiangsu, PR China. Electronic address:
Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Connexin is a transmembrane protein involved in gap junctions (GJs) formation. Our previous study found that connexin 37 (Cx37), encoded by gap junction protein alpha 4 (GJA4), expressed on fibroblasts acts as a promoter of CRC and is closely related to epithelial-mesenchymal transition (EMT) and tumor immune microenvironment.
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