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System Complexity in Influenza Infection and Vaccination: Effects upon Excess Winter Mortality.
Infect Dis Rep
April 2022
Department of Biophysics, Informatics and Medical Instrumentation, Odessa National Medical University, Valikhovsky Lane 2, 65082 Odessa, Ukraine.
Unexpected outcomes are usually associated with interventions in complex systems. Excess winter mortality (EWM) is a measure of the net effect of all competing forces operating each winter, including influenza(s) and non-influenza pathogens. In this study over 2400 data points from 97 countries are used to look at the net effect of influenza vaccination rates in the elderly aged 65+ against excess winter mortality (EWM) each year from the winter of 1980/81 through to 2019/20.
View Article and Find Full Text PDFA survey in Hong Kong on middle-aged adults revealed a low influenza vaccination uptake rate of 13%. As a heterogeneous population comprising individuals at different levels of risk for complications, effective development of strategy for improving vaccination coverage in middle-aged adults should be prioritized.
View Article and Find Full Text PDFLessons from 40 years' surveillance of influenza in England and Wales.
Epidemiol Infect
July 2008
Birmingham Research Unit of the Royal College of General Practitioners, Harborne, Birmingham, UK.
The influenza virus continues to pose a significant threat to public health throughout the world. Current avian influenza outbreaks in humans have heightened the need for improved surveillance and planning. Despite recent advances in the development of vaccines and antiviral drugs, seasonal epidemics of influenza continue to contribute significantly to general practitioner workloads, emergency hospital admissions, and deaths.
View Article and Find Full Text PDFInfluenza vaccine uptake and distribution in England and Wales using data from the General Practice Research Database, 1989/90-2003/04.
J Public Health (Oxf)
December 2005
Respiratory Diseases Department, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK.
Background: Routinely collected data from patients registered with general practices participating in the General Practice Research Database (GPRD) were used to analyse influenza vaccine uptake and distribution in England and Wales between 1989/90 and 1996/97. Major changes to influenza immunization policy were introduced in 1998 and 2000 when immunization of the elderly became age related rather than risk related. This new study examines trends in vaccine uptake for high- and low-risk patients and the impact of the policy changes on uptake in the elderly.
View Article and Find Full Text PDFMortality in children from influenza and respiratory syncytial virus.
J Epidemiol Community Health
July 2005
Birmingham Research Unit of the Royal College of General Practitioners, Lordswood House, 54 Lordswood Road, Harborne, Birmingham B17 9DB, UK.
Study Objective: To quantify mortality attributable to influenza and respiratory syncytial virus (RSV) infection in children.
Design And Methods: Comparison of death rates (all cause and certified respiratory) in England over winters 1989/90 to 1999/00 during and outside influenza and RSV circulation periods. Virus active weeks were defined from clinical and virological surveillance data.
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