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Light Environment of Arctic Solstices is Coupled With Melatonin Phase-Amplitude Changes and Decline of Metabolic Health.
J Pineal Res
January 2025
Department of Integrated Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA.
Light environment in the Arctic differs widely with the seasons. Studies of relationships between objectively measured circadian phase and amplitude of light exposure and melatonin in community-dwelling Arctic residents are lacking. This investigation combines cross-sectional (n = 24-62) and longitudinal (n = 13-27) data from week-long actigraphy (with light sensor), 24-h salivary melatonin profiles, and proxies of metabolic health.
View Article and Find Full Text PDFA novel blue-green infrastructure for providing potential drinking water source from urban stormwater through a sustainable physical-biological treatment.
Water Res
December 2024
Faculty of Applied Science, School of Engineering, University of British Columbia Okanagan Campus, Kelowna, British Columbia V1V 1V7, Canada.
In this research, a sustainable blue-green infrastructure (BGI) was developed to efficiently remove contaminants from stormwater through a combined use of modified porous asphalt (PA) and microalgae cultivation to provide a potential drinking water (DW) source. According to the results, the modified PA with powder activated carbon (PAC) could successfully reduce the level of total suspended solids (TSS), turbidity, polycyclic aromatic hydrocarbons (PAHs), oil and grease to below the DW standards but failed to efficiently remove some heavy metals (HMs) and nutrient pollutants. The results revealed that the treated stormwater was an appropriate medium for microalgae cultivation.
View Article and Find Full Text PDFA negatively charged region within carboxy-terminal domain maintains proper CTCF DNA binding.
iScience
December 2024
Center for Comparative Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, State Key Laboratory of Medical Genomics, Institute of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
As an essential regulator of higher-order chromatin structures, CCCTC-binding factor (CTCF) is a highly conserved protein with a central DNA-binding domain of 11 tandem zinc fingers (ZFs), which are flanked by amino (N-) and carboxy (C-) terminal domains of intrinsically disordered regions. Here we report that CRISPR deletion of the entire C-terminal domain of alternating charge blocks decreases CTCF DNA binding but deletion of the C-terminal fragment of 116 amino acids results in increased CTCF DNA binding and aberrant gene regulation. Through a series of genetic targeting experiments, in conjunction with electrophoretic mobility shift assay (EMSA), circularized chromosome conformation capture (4C), qPCR, chromatin immunoprecipitation with sequencing (ChIP-seq), and assay for transposase-accessible chromatin with sequencing (ATAC-seq), we uncovered a negatively charged region (NCR) responsible for weakening CTCF DNA binding and chromatin accessibility.
View Article and Find Full Text PDFThe impact of patient support and health education on diabetes management and glycemic control.
J Med Life
October 2024
Department of Family and Community Medicine, Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia.
Diabetes mellitus is a chronic and complex medical condition that can lead to significant morbidity and mortality. Maintaining an adequate blood glucose level is important for patients with diabetes, and to improve glycemic control, patients need proper support and health education, which are essential components of comprehensive diabetes care. We used a rigorous approach based on the PRISMA and Cochrane Handbook principles, specifically focusing on randomized controlled trials (RCTs) published in English from 2005 onwards.
View Article and Find Full Text PDFChange of TMJ Space Volume After Mandibular Setback BSSRO With Intended Manual Condyle Positioning in Severe Facial Asymmetric Patients.
J Craniofac Surg
December 2024
Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University Yangsan, Republic of Korea.
Purpose: This study aimed to quantitatively analyze temporomandibular joint (TMJ) space volume changes before and after bilateral sagittal split ramus osteotomy (BSSRO) with intended manual condyle positioning in patients with severe facial asymmetry.
Methods: A retrospective study was conducted, including 20 patients with facial asymmetry (menton deviation >8 mm) who underwent BSSRO with intended manual condyle positioning at a single institution. Cone beam computed tomography (CBCT) images were obtained preoperatively (T0), 2 days postoperatively (T1), and 6 months postoperatively (T2).
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