Forkhead-associated domain (FHA) is a phosphopeptide recognition domain embedded in some regulatory proteins. With similar fold type to important eukaryotic signaling molecules such as Smad2 and IRF3, the role of bacterial FHA domain is intensively pursued. Reported bacterial FHA domain roles include: regulation of glutamate and lipids production, regulation of cell shape, type III secretion, ethambutol resistance, sporulation, signal transduction, carbohydrate storage and transport, and pathogenic and symbiotic host-bacterium interactions. To provide basis for the studies of other bacterial FHA domain containing proteins, the status of bacterial FHA functionality and evolution were summarized.
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Association of baseline cytokines with antibody concentrations after diphtheria-tetanus-acellular pertussis booster vaccination in Finnish children.
Vaccine
January 2025
Institute of Biomedicine, Research Centre for Infections and Immunity, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland; InFLAMES Research Flagship Centre, University of Turku, Turku 20520, Finland. Electronic address:
Background: Despite extensive vaccinations, pertussis remains endemic and epidemic in multiple countries. The persistence of cases can be partly attributed to the significant individual variation in vaccine responses. This study evaluated the association of baseline cytokines (before booster vaccination) on antibody concentrations to Tdap-vaccine antigens.
View Article and Find Full Text PDFA reduced-dose recombinant pertussis vaccine booster in Thai adolescents: a phase 2/3, observer-blinded, randomised controlled, non-inferiority trial.
Lancet Child Adolesc Health
December 2024
Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Article Synopsis
- The study aimed to evaluate a new low-cost pertussis booster vaccine with reduced doses of key components, comparing it to existing Tdap vaccines, due to a recent increase in pertussis cases.
- Conducted in Thailand with 450 adolescents, the trial tested seroconversion rates among three vaccine groups to determine if the new vaccine was non-inferior compared to traditional options.
- Results showed that the new vaccine (ap) had a 71% seroconversion rate for anti-FHA IgG, while Tdap had a higher rate of 94%, suggesting that the new vaccine still needs further investigation to improve immunogenicity.
Immunogenicity and Protective Efficacy of an Acellular Pertussis Vaccine Candidate in a Mice Model.
Iran J Allergy Asthma Immunol
July 2024
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Acellular pertussis vaccines (aPVs) have been developed as an alternative to whole-cell pertussis vaccines (wPVs) due to their similar efficacy but reduced reactogenicity. The aPV contains three or more immunogenic components of BP. We aimed to evaluate the immunogenicity and protective potency of an aPV vaccine produced in our laboratory consisting of pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertactin (PRN) in mice.
View Article and Find Full Text PDFSeroepidemiology of pertussis immunity in five provinces of China: A population-based, cross-sectional study.
Hum Vaccin Immunother
December 2024
Department of Immunization and Prevention, Beijing Center for Disease Prevention and Control, Beijing, China.
This study aimed to evaluate the seroprevalence of and persistence of antibodies following vaccination. We recruited 6060 healthy subjects from five provinces of China during 2017-2018. Serum IgG antibodies against pertussis toxin (anti-PT IgG) and filamentous hemagglutinin (anti-FHA IgG), and serum IgA antibodies against pertussis toxin (anti-PT IgA) were measured by ELISA.
View Article and Find Full Text PDFA novel whole blood assay to quantify the release of T cell associated cytokines in response to Bordetella pertussis antigens.
J Immunol Methods
November 2024
Institute of Biomedicine, University of Turku, Turku, Finland.
Background: Bordetella pertussis continues to cause whooping cough globally even in countries with high immunisation coverage. Booster vaccinations with acellular pertussis vaccines are thus used in children, adolescents, and adults. T cell immunity is crucial for orchestrating the immune response after vaccination.
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