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Common cancer risk and statins: a population-based case-control study in a Chinese population. | LitMetric

Common cancer risk and statins: a population-based case-control study in a Chinese population.

Expert Opin Drug Saf

Min Sheng General Hospital, Cancer Center, Department of Radiation Therapy, Taipei, 168, Jingguo Road, Taoyuan City, Taoyuan County 330, Taiwan.

Published: January 2013

AI Article Synopsis

  • The study aimed to determine the relationship between statin use and the risk of developing common cancers in Taiwan.
  • Researchers analyzed data from over 6,800 patients who used statins and over 27,000 matched controls to estimate the hazard ratios for cancer risk.
  • Results indicated that statin use was associated with a lower risk of various cancers, particularly gastric, liver, and uterine cancers.

Article Abstract

Objective: To investigate whether the use of statins is associated with common cancer risk.

Methods: A population-based case-control study was conducted in Taiwan. Cases were defined as all patients who were aged 18 years and older and had received at least two statin prescriptions for use continuously for at least 6 months before a first-time diagnosis of studied cancers between the period of 2000 and 2008. The controls were matched to cases by age, sex, and index date. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by using the Cox proportional hazards model.

Results: A total of 6841 cases and 27,364 matched controls were analyzed. The adjusted hazard ratio for any statin use and cancer at any site were 0.76 (95% 0.654, 0.891). There were a significant reduced risk of gastric cancer (HR: 0.26, 95% CI: 0.107, 0.588), liver cancer (HR: 0.44, 95% CI: 0.279, 0.723) and uterine cancer (HR: 0.44, 95% CI: 0.279, 0.723) associated with any statins.

Conclusion: Overall, the statins suggested a significant reduced risk of the most common cancers in a large Chinese population, particularly in gastric, liver, and uterine cancers.

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Source
http://dx.doi.org/10.1517/14740338.2013.744392DOI Listing

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