AI Article Synopsis
- The complement system works alongside antibodies, made up of proteins C1-C9 and regulatory molecules, to support immune functions.
- It plays three main roles: enhancing phagocytosis to clear microbes, directly destroying bacteria through the membrane attack complex, and activating immune responses that recruit neutrophils.
- The text also summarizes recent findings and treatments for paroxysmal nocturnal hemoglobinuria and hereditary angioedema, along with a brief discussion on the rare disorder 3MC syndrome and potential new roles of complement factors beyond innate immunity.
Article Abstract
The complement has been identified as a complementation factor to compensate for the function of an antibody. The complement consists of C1-C9, a complement-related molecule, and its regulating molecules. Three major biological roles of the complement have been classified: First: opsonization following phagocytosis and the elimination of microbes; second: direct destruction of bacteria due to membrane attack complex (MAC); third: complement activation following the induction of anaphylactoid factors and local recruitment and activation of neutrophilic leukocytes. In this review, the basic findings and recent treatments of paroxysmal nocturnal hemoglobinuria (PNH) and hereditary angioedema (HAE) are summarized. Finally, there is a short review of a rare autosomal recessive disorder of 3MC syndrome and new biological functions of complement factors except for that of innate immunity are proposed.
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