The radiation-induced bystander effect (RIBE) has been experimentally observed for different types of radiation, cell types, and cell culture conditions. However, the behavior of signal transmission between unirradiated and irradiated cells is not well known. In this study, we have developed a new model for RIBE based on the diffusion of soluble factors in cell cultures using a Monte Carlo technique. The model involves the signal emission probability from bystander cells following Poisson statistics. Simulations with this model show that the spatial configuration of the bystander cells agrees well with that of corresponding experiments, where the optimal emission probability is estimated through a large number of simulation runs. It was suggested that the most likely probability falls within 0.63-0.92 for mean number of the emission signals ranging from 1.0 to 2.5.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502842 | PMC |
| http://dx.doi.org/10.1155/2012/389095 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Significance of the Response: Beyond the Mechanics of DNA Damage and Repair-Physiological, Genetic, and Systemic Aspects of Radiosensitivity in Higher Organisms.
Int J Mol Sci
December 2024
Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Classical radiation biology as we understand it clearly identifies genomic DNA as the primary target of ionizing radiation. The evidence appears rock-solid: ionizing radiation typically induces DSBs with a yield of ~30 per cell per Gy, and unrepaired DSBs are a very cytotoxic lesion. We know very well the kinetics of induction and repair of different types of DNA damage in different organisms and cell lines.
View Article and Find Full Text PDFSTUDY OF CHROMOSOME STABILITY OF HUMAN SOMATIC CELLS IN THE DEVELOPMENT OF THE SECONDARY RADIATION-INDUCED BYSTANDER EFFECT.
Probl Radiac Med Radiobiol
December 2024
State Institution «National Research Center of Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine.
Objective: To establish the level of chromosomal instability in human peripheral blood lymphocytes during thedevelopment of secondary radiation-induced bystander effect.
Materials And Methods: Human peripheral blood lymphocytes; culture of human non-small-cell lung cancer cell lineA549 (irradiated in vitro by 137Cs in a dose of 0.50 Gy/unirradiated).
Radiation-induced Bystander Effect in Starfish (Patiria pectinifera) Oocytes.
Radiat Res
January 2025
Integrated Center for Science and Humanities, Fukushima Medical University, Fukushima, 960-8516, Japan.
Although multiple studies suggest that ionizing radiation can induce bystander effects (radiation-induced bystander effect, RIBE) in cultured cell lines, it is still unclear whether RIBE is evolutionarily conserved in invertebrates. In this study, we investigated the frequency of cell death of unirradiated starfish (Patiria pectinifera) oocytes co-cultured with oocytes irradiated with X rays (0, 2 and 4 Gy). We observed increased frequencies of cell death determined by morphological abnormality and TUNEL-positive cells in unirradiated oocytes co-cultured with oocytes irradiated with 2 Gy or 4 Gy oocytes.
View Article and Find Full Text PDFRole of damaged mitochondrial transfer in alpha-particle generator Pb radiation-induced bystander effect.
Theranostics
October 2024
Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Pb, a promising alphaparticle generator of Bi, has aroused much interest as a therapeutic radionuclide. For the development of targeted alpha therapy (TAT), it is important to determine the contribution of targeted effects in irradiated cells, and also of non-targeted effects in non-irradiated bystander cells. Currently, the critical roles of mitochondrial transfer in cellular crosstalk have garnered significant attention.
View Article and Find Full Text PDFRadiation-Induced Macrovessel/Microvessel Disease.
Arterioscler Thromb Vasc Biol
December 2024
Free Radical and Radiation Biology Program, Department of Radiation Oncology (B.G.A., K.A.M., I.M.G.), Carver College of Medicine, University of Iowa.
Radiation therapy (RT) is a cornerstone in cancer treatment (used in 50% of cases), yet challenges persist because damage to normal tissue through direct impact of radiation or bystander effects is inevitable. Injury of macrovessels by RT manifests as obstructive disease, which is akin to atherosclerotic disease. Historically observed in coronary arteries of patients treated for breast cancer and lymphoma, it also affects patients receiving contemporary therapy for lung and chest cancers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!