AI Article Synopsis
- The study investigated the persistence of antibodies in children after receiving three doses of pentavalent vaccines (DTwP, hepatitis B, and Hib) and their response to a booster dose of DTwP-Hib.
- Results showed that both types of pentavalent vaccines elicited a strong immune response at 15-18 months, with most children achieving protective antibody levels after the booster, though the pertussis response was slightly lower (~78%).
- The booster dose was generally safe, with some children experiencing mild reactions like fever and local pain, indicating that the primary vaccinations provided long-lasting immunity and a good response to the booster.
Article Abstract
Objectives: Antibody persistence in children following three doses of primary vaccination with diphtheria, tetanus, whole-cell-pertussis (DTwP), hepatitis B, and Haemophilus influenzae type b (Hib) vaccines (SIIL Pentavac vaccine vs. Easyfive(®) of Panacea Biotec), and response to the booster dose of DTwP-Hib (Quadrovax(®)) vaccine.
Methods: Children who completed their primary immunization were assessed for antibodies at 15-18 months of age, and then given a booster dose of DTwP-Hib vaccine. Reactogenicity and safety of the booster dose was evaluated.
Results: Both pentavalent vaccines demonstrated a good immune response at 15-18 months. Following the booster dose, all vaccinated subjects achieved protective titers against diphtheria, tetanus and Hib, whereas the response to pertussis antigen was ~78%. Fever and irritability was noted in 24%, local pain in 51%, and swelling in 36% of the children following booster dose.
Conclusions: Primary immunization with either pentavalent vaccine induced an excellent immunity lasting till the second year of life. A booster dose with DTwP-Hib (Quadrovax(®)) vaccine effectuated a good anamnestic response to all vaccine components, being specially strong for Hib in children previously vaccinated with SIIL liquid pentavalent vaccine (Pentavac(®)). Also, the safety profile of SIIL quadrivalent vaccine (Quadrovax(®)) administered as booster dose was acceptable.
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| http://dx.doi.org/10.1016/j.vaccine.2012.11.038 | DOI Listing |
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