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Impact of Upper Limb Function on Activities of Daily Living and Quality of Life in Huntington's Disease.
J Clin Med
December 2024
Neurology Department, Burgos University Hospital, 09006 Burgos, Spain.
: Huntington's disease (HD) is a neurodegenerative movement disorder associated with significant disability and impairment of Activities of Daily Living (ADLs). The impact of upper limb disability on quality of life (QoL) and its influence on ADLs is not well known yet. The aim of this study was to describe the manipulative dexterity, strength, and manual eye coordination of patients with manifest and premanifest-HD compared to healthy individuals and to analyze its influence on ADLs and QoL.
View Article and Find Full Text PDFThe Challenges and Opportunities for Performance Enhancement in Resonant Fiber Optic Gyroscopes.
Sensors (Basel)
January 2025
Department of Electrical Engineering, Indian Institute of Technology Madras, Chennai 600036, India.
In the last decade, substantial progress has been made to improve the performance of optical gyroscopes for inertial navigation applications in terms of critical parameters such as bias stability, scale factor stability, and angular random walk (ARW). Specifically, resonant fiber optic gyroscopes (RFOGs) have emerged as a viable alternative to widely popular interferometric fiber optic gyroscopes (IFOGs). In a conventional RFOG, a single-wavelength laser source is used to generate counter-propagating waves in a ring resonator, for which the phase difference is measured in terms of the resonant frequency shift to obtain the rotation rate.
View Article and Find Full Text PDFThe Role of Fractalkine in Diabetic Retinopathy: Pathophysiology and Clinical Implications.
Int J Mol Sci
January 2025
Department of Ophthalmology, National Taiwan University Hospital, No. 7, Chung Shan S. Rd. (Zhongshan S. Rd.), Zhongzheng Dist., Taipei City 100225, Taiwan.
Diabetic retinopathy (DR) is a complication of diabetes, characterized by progressive microvascular dysfunction that can result in vision loss. Chronic hyperglycemia drives oxidative stress, endothelial dysfunction, and inflammation, leading to retinal damage and complications such as neovascularization. Current treatments, including anti-VEGF agents, have limitations, necessitating the exploration of alternative therapeutic strategies.
View Article and Find Full Text PDFAtypical B-Cell Acute Lymphoblastic Leukemia with iAMP21 in the Context of Constitutional Ring Chromosome 21: A Case Report and Review of the Genetic Insights.
Int J Mol Sci
January 2025
Centro de Investigación Biomédica en Red de Cáncer, CIBERONC CB16/12/00284, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Recent studies have demonstrated the association between constitutional ring chromosome 21 (r(21)c) and the development of B-cell acute lymphoblastic leukemia (B-ALL) with intrachromosomal amplification of chromosome 21 (iAMP21). iAMP21 acts as a driver which is often accompanied by secondary alterations that influence disease progression. Here, we report an atypical case of iAMP21 B-ALL with a unique molecular profile in the context of r(21)c.
View Article and Find Full Text PDFAn Evidence-Based Narrative Review of Scleral Hypoxia Theory in Myopia: From Mechanisms to Treatments.
Int J Mol Sci
January 2025
College of Physical Education, Hunan Normal University, Changsha 410012, China.
Myopia is one of the dominant causes of visual impairment in the world. Pathological myopia could even lead to other serious eye diseases. Researchers have reached a consensus that myopia could be caused by both environmental and genetic risk factors.
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