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Facial Hyperpigmentation Following Adalimumab.
Curr Drug Saf
October 2024
National Center Chalbi Belkahia of Pharmacovigilance, Department of collection and analysis of adverse effects, Tunis, Tunisia.
Background: Tumor necrosis factor alpha (TNF-α) inhibitors, such as adalimumab, have significantly advanced the treatment of inflammatory diseases. However, these therapies are associated with various cutaneous adverse reactions.
Case Presentation: We describe two rare instances of isolated facial hyperpigmentation induced by adalimumab.
First report on the occurrence of psoroptic mange in llamas (Lama glama) of the Andean region.
Parasitol Res
September 2024
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), C1425FQB, Buenos Aires, Argentina.
Article Synopsis
- An outbreak of mange caused by Psoroptes sp. was identified in a llama herd in Jujuy province, Argentina, with symptoms including hair loss, skin inflammation, and ear drainage.
- Microscopic analysis confirmed the presence of Psoroptes mites, and histological studies indicated an allergic reaction with mixed inflammatory cells.
- The research also revealed genetic links between local llama infections and similar infections in rabbits and bighorn sheep, emphasizing the need for further studies to manage these parasitic issues in South American camelids.
Inhibitive Mechanism of Loquat Flower Isolate on Tyrosinase Activity and Melanin Synthesis in Mouse Melanoma B16 Cells.
Biomolecules
July 2024
School of Agriculture, Food, and Ecosystem Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.
Melanin naturally exists in organisms and is synthetized by tyrosinase (TYR); however, its over-production may lead to aberrant pigmentation and skin conditions. Loquat ( (Thunb.) Lindl.
View Article and Find Full Text PDFCompounds with Antioxidant Activity, and Inhibition Potential against Tyrosinase, Melanin, Hyaluronidase, Elastase, and Collagenase.
Pharmaceuticals (Basel)
July 2024
COBIOSA, Road of Alpedrete, 6, 28400 Collado Villalba, Spain.
In our study, using chromatographic techniques, we isolated three bioactive compounds, which were structurally elucidated as ()-2-(3-(3,4-dimethoxyphenyl)acrylamido)--methylbenzamide (), 4-Hydroxyquinoline-2-carboxylic acid (), and ()-2-Cyano-3-(4-hydroxyphenyl)acrylic acid (), using spectroscopic methods. The anti-melanogenic, anti-inflammatory, antioxidant, and anti-aging properties were evaluated in vitro by measuring the activity of pharmacological targets including tyrosinase, melanin, NF-κB, hyaluronidase, elastase, collagenase, and Nrf2. Our results show that compound is the most active with IC values of 14.
View Article and Find Full Text PDFMechanism of the wine pomace tannin in hyperpigmentation inhibition: Impact on signaling pathways, cell proliferation, and tyrosinase activity.
Int J Biol Macromol
October 2024
College of Science, Shantou University, Shantou 515063, China; Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou 515063, China. Electronic address:
After winemaking, tannins with high polymerization remain in the pomace. Utilizing these tannin fractions is a concern for the wine industry. While tannins show potential in treating hyperpigmentation, their mechanisms in vivo and at the cellular level are unclear.
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