Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu(I), Ag(I), and Au(III) leads to 1,4-adducts in good isolated yields: no organometallic precursor need be formed.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959802 | PMC |
| http://dx.doi.org/10.1021/ja309409e | DOI Listing |
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